2oyc
From Proteopedia
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|GENE= PDXP, PLP, PLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= PDXP, PLP, PLPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0647 NagD]</span> | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0647 NagD]</span> | ||
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyc OCA], [http://www.ebi.ac.uk/pdbsum/2oyc PDBsum | + | |RELATEDENTRY= |
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyc OCA], [http://www.ebi.ac.uk/pdbsum/2oyc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oyc RCSB]</span> | ||
}} | }} | ||
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[[Category: structural genomic]] | [[Category: structural genomic]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:25:06 2008'' |
Revision as of 01:25, 31 March 2008
| |||||||
| , resolution 1.720Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | and | ||||||
| Ligands: | , , | ||||||
| Gene: | PDXP, PLP, PLPP (Homo sapiens) | ||||||
| Activity: | Pyridoxal phosphatase, with EC number 3.1.3.74 | ||||||
| Domains: | NagD | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of human pyridoxal phosphate phosphatase
Overview
The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
About this Structure
2OYC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037
Page seeded by OCA on Mon Mar 31 04:25:06 2008
Categories: Homo sapiens | Pyridoxal phosphatase | Single protein | Almo, S C. | Burley, S K. | Freeman, J. | Izuka, M. | NYSGXRC, New York Structural GenomiX Research Consortium. | Ramagopal, U A. | Sauder, J M. | Toro, R. | Hydrolase | New york structural genomix research consortium | Nysgxrc | Phosphatase | Protein structure initiative | Psi-2 | Structural genomic
