2oyp
From Proteopedia
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|PDB= 2oyp |SIZE=350|CAPTION= <scene name='initialview01'>2oyp</scene>, resolution 1.952Å | |PDB= 2oyp |SIZE=350|CAPTION= <scene name='initialview01'>2oyp</scene>, resolution 1.952Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Havcr2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= Havcr2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyp OCA], [http://www.ebi.ac.uk/pdbsum/2oyp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oyp RCSB]</span> | ||
}} | }} | ||
| Line 28: | Line 31: | ||
[[Category: Nathenson, S G.]] | [[Category: Nathenson, S G.]] | ||
[[Category: Ramagopal, U A.]] | [[Category: Ramagopal, U A.]] | ||
| - | [[Category: | + | [[Category: t-cell immunoglobulin mucin]] |
| - | [[Category: tim-3 | + | [[Category: tim-3]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:25:10 2008'' |
Revision as of 01:25, 31 March 2008
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| , resolution 1.952Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | Havcr2 (Mus musculus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface
Overview
The T cell immunoglobulin mucin (Tim) family of receptors regulates effector CD4(+) T cell functions and is implicated in autoimmune and allergic diseases. Tim-3 induces immunological tolerance, and engagement of the Tim-3 immunoglobulin variable (IgV) domain by galectin-9 is important for appropriate termination of T helper 1-immune responses. The 2 A crystal structure of the Tim-3 IgV domain demonstrated that four cysteines, which are invariant within the Tim family, form two noncanonical disulfide bonds, resulting in a surface not present in other immunoglobulin superfamily members. Biochemical and biophysical studies demonstrated that this unique structural feature mediates a previously unidentified galectin-9-independent binding process and suggested that this structural feature is conserved within the entire Tim family. The current work provided a graphic example of the relationship between sequence, structure, and function and suggested that the interplay between multiple Tim-3-binding activities contributes to the regulated assembly of signaling complexes required for effective Th1-mediated immunity.
About this Structure
2OYP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface., Cao E, Zang X, Ramagopal UA, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, Dilorenzo TP, Allison JP, Nathenson SG, Almo SC, Immunity. 2007 Mar;26(3):311-21. PMID:17363302
Page seeded by OCA on Mon Mar 31 04:25:10 2008
