2oyv
From Proteopedia
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|PDB= 2oyv |SIZE=350|CAPTION= <scene name='initialview01'>2oyv</scene> | |PDB= 2oyv |SIZE=350|CAPTION= <scene name='initialview01'>2oyv</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2oyw|2OYW]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyv OCA], [http://www.ebi.ac.uk/pdbsum/2oyv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oyv RCSB]</span> | ||
}} | }} | ||
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[[Category: type i turn]] | [[Category: type i turn]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:25:16 2008'' |
Revision as of 01:25, 31 March 2008
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| Ligands: | |||||||
| Related: | 2OYW
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Neurotensin in DPC micelles
Overview
Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.
About this Structure
2OYV is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition., Coutant J, Curmi PA, Toma F, Monti JP, Biochemistry. 2007 May 15;46(19):5656-63. Epub 2007 Apr 19. PMID:17441729
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