5nv1

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'''Unreleased structure'''
 
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The entry 5nv1 is ON HOLD until Paper Publication
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==SH3 domain from Mouse cortactin (C 2 2 21 crystal form)==
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<StructureSection load='5nv1' size='340' side='right' caption='[[5nv1]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
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Authors: Twafra, S., Dessau, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5nv1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NV1 FirstGlance]. <br>
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Description: SH3 domain from Mouse cortactin (C 2 2 21 crystal form)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nv1 OCA], [http://pdbe.org/5nv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nv1 RCSB], [http://www.ebi.ac.uk/pdbsum/5nv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nv1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SRC8_MOUSE SRC8_MOUSE]] Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:17403031</ref> <ref>PMID:22262902</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Dessau, M]]
[[Category: Twafra, S]]
[[Category: Twafra, S]]
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[[Category: Dessau, M]]
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[[Category: Cancer]]
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[[Category: Cortactin]]
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[[Category: Invadopodium]]
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[[Category: Sh3 domain]]
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[[Category: Signaling]]
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[[Category: Signaling protein]]

Revision as of 16:06, 15 August 2018

SH3 domain from Mouse cortactin (C 2 2 21 crystal form)

5nv1, resolution 1.51Å

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