6e9d

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m (Protected "6e9d" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{Large structure}}
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==Sub-2 Angstrom Ewald Curvature-Corrected Single-Particle Cryo-EM Reconstruction of AAV-2 L336C==
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The entry 6e9d is ON HOLD
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<StructureSection load='6e9d' size='340' side='right' caption='[[6e9d]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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== Structural highlights ==
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Authors: Tan, Y.Z., Aiyer, S., Mietzsch, M., Hull, J.A., McKenna, R., Baker, T.S., Agbandje-McKenna, M., Lyumkis, D.
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<table><tr><td colspan='2'>[[6e9d]] is a 60 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E9D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E9D FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e9d OCA], [http://pdbe.org/6e9d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e9d RCSB], [http://www.ebi.ac.uk/pdbsum/6e9d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e9d ProSAT]</span></td></tr>
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Description: Sub-2 Angstrom Ewald Curvature-Corrected Single-Particle Cryo-EM Reconstruction of AAV-2 L336C
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</table>
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[[Category: Unreleased Structures]]
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{{Large structure}}
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[[Category: Baker, T.S]]
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== Function ==
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[[Category: Tan, Y.Z]]
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[[http://www.uniprot.org/uniprot/CAPSD_AAV2S CAPSD_AAV2S]] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.<ref>PMID:10684294</ref> <ref>PMID:11961250</ref> <ref>PMID:16940508</ref> <ref>PMID:9445046</ref>
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[[Category: Hull, J.A]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Agbandje-McKenna, M]]
[[Category: Aiyer, S]]
[[Category: Aiyer, S]]
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[[Category: Mckenna, R]]
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[[Category: Baker, T S]]
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[[Category: Hull, J A]]
[[Category: Lyumkis, D]]
[[Category: Lyumkis, D]]
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[[Category: McKenna, R]]
[[Category: Mietzsch, M]]
[[Category: Mietzsch, M]]
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[[Category: Agbandje-Mckenna, M]]
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[[Category: Tan, Y Z]]
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[[Category: Aav-2 l336c]]
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[[Category: Ewald sphere curvature correction]]
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[[Category: Gene therapy]]
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[[Category: Per particle ctf]]
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[[Category: Virus like particle]]

Revision as of 16:20, 15 August 2018

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Sub-2 Angstrom Ewald Curvature-Corrected Single-Particle Cryo-EM Reconstruction of AAV-2 L336C

6e9d, resolution 1.86Å

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