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6ffv
From Proteopedia
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<StructureSection load='6ffv' size='340' side='right' caption='[[6ffv]], [[Resolution|resolution]] 2.01Å' scene=''> | <StructureSection load='6ffv' size='340' side='right' caption='[[6ffv]], [[Resolution|resolution]] 2.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6ffv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FFV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6ffv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"thiobacillus_denitrificans"_beijerinck_1904 "thiobacillus denitrificans" beijerinck 1904]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FFV FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tbd_2719 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36861 "Thiobacillus denitrificans" Beijerinck 1904])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ffv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ffv OCA], [http://pdbe.org/6ffv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ffv RCSB], [http://www.ebi.ac.uk/pdbsum/6ffv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ffv ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ffv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ffv OCA], [http://pdbe.org/6ffv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ffv RCSB], [http://www.ebi.ac.uk/pdbsum/6ffv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ffv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Uptake of vitamin B12 is essential for many prokaryotes, but in most cases the membrane proteins involved are yet to be identified. We present the biochemical characterization and high-resolution crystal structure of BtuM, a predicted bacterial vitamin B12 uptake system. BtuM binds vitamin B12 in its base-off conformation, with a cysteine residue as axial ligand of the corrin cobalt ion. Spectroscopic analysis indicates that the unusual thiolate coordination allows for decyanation of vitamin B12. Chemical modification of the substrate is a property other characterized vitamin B12-transport proteins do not exhibit. | ||
| + | |||
| + | Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM.,Rempel S, Colucci E, de Gier JW, Guskov A, Slotboom DJ Nat Commun. 2018 Aug 2;9(1):3038. doi: 10.1038/s41467-018-05441-9. PMID:30072686<ref>PMID:30072686</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6ffv" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Thiobacillus denitrificans beijerinck 1904]] | ||
[[Category: Colucci, E]] | [[Category: Colucci, E]] | ||
[[Category: Gier, J W.de]] | [[Category: Gier, J W.de]] | ||
Revision as of 16:41, 15 August 2018
The crystal structure of BtuM cobalamin transporter
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