2p22
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2p22 |SIZE=350|CAPTION= <scene name='initialview01'>2p22</scene>, resolution 2.70Å | |PDB= 2p22 |SIZE=350|CAPTION= <scene name='initialview01'>2p22</scene>, resolution 2.70Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= VPS23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), VPT28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), VPS37 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), Mvb12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | |GENE= VPS23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), VPT28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), VPS37 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), Mvb12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2f66|2F66]], [[2f6m|2F6M]], [[2caz|2CAZ]], [[|]], [[2j9v|2J9V]], [[2j9u|2J9U]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p22 OCA], [http://www.ebi.ac.uk/pdbsum/2p22 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p22 RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Hurley, J H.]] | [[Category: Hurley, J H.]] | ||
[[Category: Kostelansky, MS]] | [[Category: Kostelansky, MS]] | ||
| - | [[Category: SO4]] | ||
[[Category: endosomal sorting complex required for transport]] | [[Category: endosomal sorting complex required for transport]] | ||
[[Category: endosome]] | [[Category: endosome]] | ||
| Line 38: | Line 40: | ||
[[Category: vps37]] | [[Category: vps37]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:27:23 2008'' |
Revision as of 01:27, 31 March 2008
| |||||||
| , resolution 2.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | VPS23 (Saccharomyces cerevisiae), VPT28 (Saccharomyces cerevisiae), VPS37 (Saccharomyces cerevisiae), Mvb12 (Saccharomyces cerevisiae) | ||||||
| Related: | 2F66, 2F6M, 2CAZ, [[|]], 2J9V, 2J9U
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the Yeast ESCRT-I Heterotetramer Core
Overview
The endosomal sorting complex required for transport-I (ESCRT-I) complex, which is conserved from yeast to humans, directs the lysosomal degradation of ubiquitinated transmembrane proteins and the budding of the HIV virus. Yeast ESCRT-I contains four subunits, Vps23, Vps28, Vps37, and Mvb12. The crystal structure of the heterotetrameric ESCRT-I complex reveals a highly asymmetric complex of 1:1:1:1 subunit stoichiometry. The core complex is nearly 18 nm long and consists of a headpiece attached to a 13 nm stalk. The stalk is important for cargo sorting by ESCRT-I and is proposed to serve as a spacer regulating the correct disposition of cargo and other ESCRT components. Hydrodynamic constraints and crystallographic structures were used to generate a model of intact ESCRT-I in solution. The results show how ESCRT-I uses a combination of a rigid stalk and flexible tethers to interact with lipids, cargo, and other ESCRT complexes over a span of approximately 25 nm.
About this Structure
2P22 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer., Kostelansky MS, Schluter C, Tam YY, Lee S, Ghirlando R, Beach B, Conibear E, Hurley JH, Cell. 2007 May 4;129(3):485-98. Epub 2007 Apr 19. PMID:17442384
Page seeded by OCA on Mon Mar 31 04:27:23 2008
