2n2c
From Proteopedia
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==NMR Structure of TDP-43 prion-like hydrophobic helix in DPC== | ==NMR Structure of TDP-43 prion-like hydrophobic helix in DPC== | ||
<StructureSection load='2n2c' size='340' side='right' caption='[[2n2c]], [[NMR_Ensembles_of_Models | 6 NMR models]]' scene=''> | <StructureSection load='2n2c' size='340' side='right' caption='[[2n2c]], [[NMR_Ensembles_of_Models | 6 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2n2c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N2C FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2n2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N2C FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2c OCA], [http://pdbe.org/2n2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n2c RCSB], [http://www.ebi.ac.uk/pdbsum/2n2c PDBsum]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TARDBP, TDP43 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2c OCA], [http://pdbe.org/2n2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n2c RCSB], [http://www.ebi.ac.uk/pdbsum/2n2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n2c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref> | [[http://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref> | ||
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| + | ==See Also== | ||
| + | *[[Tdp-43|Tdp-43]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Lim, L]] | [[Category: Lim, L]] | ||
[[Category: Song, J]] | [[Category: Song, J]] | ||
Revision as of 17:18, 15 August 2018
NMR Structure of TDP-43 prion-like hydrophobic helix in DPC
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