Penicillin-binding protein
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Penicillin-binding protein''' (PBP) is a bacterial protein which binds antibiotics. There are several PBPs in each organism. PBPs are involved in the synthesis of bacterial cell wall<ref>PMID:1103132</ref>. The PBP are classified to high-molecular weight and low-molecular weight groups. | + | '''Penicillin-binding protein''' (PBP) is a bacterial protein which binds antibiotics. There are several PBPs in each organism. PBPs are involved in the synthesis of bacterial cell wall<ref>PMID:1103132</ref>. The PBP are classified to high-molecular weight and low-molecular weight groups. |
== Relevance == | == Relevance == | ||
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**[[4cjn]] – SaPBP + quinazolinine derivative<br /> | **[[4cjn]] – SaPBP + quinazolinine derivative<br /> | ||
| - | *'''D-alanyl-D-alanine carboxypeptidase''' | ||
| - | |||
| - | **[[1w79]], [[1w8q]] – AcDDP – ''Actinomadura''<br /> | ||
| - | **[[3pte]], [[1skf]] – StDDP – ''Streptomyces''<br /> | ||
| - | **[[4rye]] – MtDDP <br /> | ||
| - | **[[5fsr]] – EcDDP <br /> | ||
| - | **[[1es2]], [[1es3]], [[1es4]], [[1es5]], [[1esi]], [[1j9m]] – StDDP (mutant) <br /> | ||
| - | **[[1lbu]] – DDP + Zn – ''Streptomyces albus''<br /> | ||
| - | **[[2wke]], [[1w8y]], [[2vgj]], [[2vgk]], [[4ben]] - AcDDP + antibiotic<br /> | ||
| - | **[[1cef]], [[1ceg]], [[1hvb]], [[1pw1]], [[1pw8]], [[1pwc]], [[1pwd]], [[1pwg]] – StDDP + antibiotic<br /> | ||
| - | **[[2xdm]], [[2xk1]], [[2xln]], [[2y4a]], [[2y55]], [[2y59]], [[3zvt]], [[3zvw]] – AcDDP + boronic acid derivative<br /> | ||
| - | **[[1ikg]], [[1iki]] – StDDP + peptidoglycan fragment<br /> | ||
| - | **[[1mpl]] - StDDP + phosphonate inhibitor<br /> | ||
| - | **[[1scw]], [[1sde]] - StDDP + cyclic phosphate inhibitor<br /> | ||
| - | **[[1yqs]] - StDDP + sultam inhibitor<br /> | ||
| - | **[[3zcz]] – AcDDP + inhibitor<br /> | ||
| - | **[[5j8x]] – EcDDP + inhibitor<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:51, 16 August 2018
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3D structures of penicillin-binding protein
Updated on 16-August-2018
References
- ↑ Spratt BG. Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Proc Natl Acad Sci U S A. 1975 Aug;72(8):2999-3003. PMID:1103132
- ↑ Beadle BM, Nicholas RA, Shoichet BK. Interaction energies between beta-lactam antibiotics and E. coli penicillin-binding protein 5 by reversible thermal denaturation. Protein Sci. 2001 Jun;10(6):1254-9. PMID:11369864 doi:http://dx.doi.org/10.1110/ps.52001
- ↑ Kishida H, Unzai S, Roper DI, Lloyd A, Park SY, Tame JR. Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics. Biochemistry. 2006 Jan 24;45(3):783-92. PMID:16411754 doi:10.1021/bi051533t
