Peptidyl-tRNA hydrolase
From Proteopedia
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry [[3vjr]])' scene='55/551222/Cv/1'> |
== Function == | == Function == | ||
'''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability. | '''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability. | ||
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**[[4olj]] – AbPTH (mutant)<BR /> | **[[4olj]] – AbPTH (mutant)<BR /> | ||
**[[4p7b]] – PTH – ''Salmonella enterica''<BR /> | **[[4p7b]] – PTH – ''Salmonella enterica''<BR /> | ||
| - | **[[2mjl]], [[4zxp]], [[5ivp]] – VcPTH – ''Vibrio cholerae''<BR /> | + | **[[2mjl]], [[4zxp]], [[5ivp]], [[5gvz]] – VcPTH – ''Vibrio cholerae''<BR /> |
**[[4z86]], [[5b6j]], [[5ekt]], [[5ike]], [[5imb]] – VcPTH (mutant)<BR /> | **[[4z86]], [[5b6j]], [[5ekt]], [[5ike]], [[5imb]] – VcPTH (mutant)<BR /> | ||
**[[4qt4]] – PTH – ''Streptococcus pyogenes''<BR /> | **[[4qt4]] – PTH – ''Streptococcus pyogenes''<BR /> | ||
Revision as of 09:52, 16 August 2018
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3D Structures of peptidyl-tRNA hydrolase
Updated on 16-August-2018
References
- ↑ Das G, Varshney U. Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis. Microbiology. 2006 Aug;152(Pt 8):2191-5. PMID:16849786 doi:http://dx.doi.org/10.1099/mic.0.29024-0
- ↑ Ito K, Murakami R, Mochizuki M, Qi H, Shimizu Y, Miura KI, Ueda T, Uchiumi T. Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase. Nucleic Acids Res. 2012 Aug 25. PMID:22923517 doi:10.1093/nar/gks790
