Phosphomannomutase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Human phosphomannomutase 1 complex with α-D-mannose-1-phosphate and Mg+2 ion (green) (PDB entry [[2fue]])' scene='48/481638/Cv/1'> |
== Function == | == Function == | ||
'''Phosphomannomutase''' (PMM) catalyzes the conversion of α-D-mannose 1-phosphate to D-mannose 6-phosphate. PMM participates in fructose and mannose metabolism. | '''Phosphomannomutase''' (PMM) catalyzes the conversion of α-D-mannose 1-phosphate to D-mannose 6-phosphate. PMM participates in fructose and mannose metabolism. | ||
| Line 19: | Line 19: | ||
**[[1k2y]] – PaPMM (mutant) – ''Pseudomonas aeruginosa''<br /> | **[[1k2y]] – PaPMM (mutant) – ''Pseudomonas aeruginosa''<br /> | ||
**[[1k35]] – PaPMM<br /> | **[[1k35]] – PaPMM<br /> | ||
| + | **[[5ue7]] - PMM – ''Candida albicans''<br /> | ||
**[[2amy]], [[2q4r]] – hPMM2 – human<br /> | **[[2amy]], [[2q4r]] – hPMM2 – human<br /> | ||
**[[2fuc]] – hPMM1 + Mg<br /> | **[[2fuc]] – hPMM1 + Mg<br /> | ||
| + | **[[6cfr]], [[6cfs]], [[6cft]], [[6cfu]] – hPMM1 (mutant) + Mg<br /> | ||
| + | **[[6cfv]] – hPMM1 + Mg + inosine<br /> | ||
**[[2i54]] – LmPMM + Mg – ''Leishmania Mexicana''<br /> | **[[2i54]] – LmPMM + Mg – ''Leishmania Mexicana''<br /> | ||
**[[3f9r]] - PMM + Mg – ''Trypanosoma brucei''<br /> | **[[3f9r]] - PMM + Mg – ''Trypanosoma brucei''<br /> | ||
Revision as of 08:33, 20 August 2018
| |||||||||||
3D Structures of phosphomannomutase
Updated on 20-August-2018
References
- ↑ Matthijs G, Schollen E, Pardon E, Veiga-Da-Cunha M, Jaeken J, Cassiman JJ, Van Schaftingen E. Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome). Nat Genet. 1997 May;16(1):88-92. PMID:9140401 doi:10.1038/ng0597-88
- ↑ Silvaggi NR, Zhang C, Lu Z, Dai J, Dunaway-Mariano D, Allen KN. The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26. Epub 2006 Mar 15. PMID:16540464 doi:http://dx.doi.org/10.1074/jbc.M601505200
