6aog

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m (Protected "6aog" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6aog is ON HOLD until Paper Publication
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==Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)==
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<StructureSection load='6aog' size='340' side='right' caption='[[6aog]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6aog]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AOG FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aog OCA], [http://pdbe.org/6aog PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aog RCSB], [http://www.ebi.ac.uk/pdbsum/6aog PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aog ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Chen, Z]]
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[[Category: Li, Y]]
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[[Category: Lu, H]]
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[[Category: Thomas, S B]]
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[[Category: Dhfr]]
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[[Category: Oxidoreductase]]
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[[Category: Pyrimethamine]]
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[[Category: Toxoplasma gondii]]

Revision as of 06:03, 22 August 2018

Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)

6aog, resolution 3.20Å

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