6ar4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of PICK1 in complex with the small molecule inhibitor 31596== | |
| - | + | <StructureSection load='6ar4' size='340' side='right' caption='[[6ar4]], [[Resolution|resolution]] 1.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ar4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AR4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BQA:N-[4-(4-bromophenyl)-1-{[2-(trifluoromethyl)phenyl]methyl}piperidine-4-carbonyl]-3-cyclopropyl-L-alanine'>BQA</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ar4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ar4 OCA], [http://pdbe.org/6ar4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ar4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ar4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ar4 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PICK1_HUMAN PICK1_HUMAN]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.<ref>PMID:20403402</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Marcotte, D]] | [[Category: Marcotte, D]] | ||
| + | [[Category: Actin binding protein]] | ||
| + | [[Category: Pdz domain pdz inhibitor]] | ||
Revision as of 06:03, 22 August 2018
Crystal structure of PICK1 in complex with the small molecule inhibitor 31596
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