6dlz

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'''Unreleased structure'''
 
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The entry 6dlz is ON HOLD until Paper Publication
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==Open state GluA2 in complex with STZ after micelle signal subtraction==
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<StructureSection load='6dlz' size='340' side='right' caption='[[6dlz]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6dlz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLZ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYZ:CYCLOTHIAZIDE'>CYZ</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlz OCA], [http://pdbe.org/6dlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlz RCSB], [http://www.ebi.ac.uk/pdbsum/6dlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Sobolevsky, A I]]
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[[Category: Twomey, E C]]
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[[Category: Vassilevski, A A]]
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[[Category: Yelshanskaya, M V]]
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[[Category: Ion channel]]
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[[Category: Transport protein]]

Revision as of 06:08, 22 August 2018

Open state GluA2 in complex with STZ after micelle signal subtraction

6dlz, resolution 3.90Å

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