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Progesterone receptor

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* Progesterone receptor residues 72-195
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**[[4x8y]] – hPR - human<br />
* Progesterone receptor DNA-binding domain residues 399-476
* Progesterone receptor DNA-binding domain residues 399-476
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**[[2c7a]] – hPR DBD + DNA - human<br />
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**[[2c7a]] – hPR DBD + DNA<br />
* Progesterone receptor ligand-binding domain residues 673-933
* Progesterone receptor ligand-binding domain residues 673-933

Revision as of 10:24, 26 August 2018

Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry 2w8y)

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3D Structures of progesterone receptor

Updated on 26-August-2018

References

  1. ↑ Lange CA, Yee D. Progesterone and breast cancer. Womens Health (Lond). 2008 Mar;4(2):151-62. doi: 10.2217/17455057.4.2.151. PMID:19072517 doi:http://dx.doi.org/10.2217/17455057.4.2.151
  2. ↑ Cui X, Schiff R, Arpino G, Osborne CK, Lee AV. Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy. J Clin Oncol. 2005 Oct 20;23(30):7721-35. doi: 10.1200/JCO.2005.09.004. PMID:16234531 doi:http://dx.doi.org/10.1200/JCO.2005.09.004
  3. ↑ Raaijmakers HC, Versteegh JE, Uitdehaag JC. The X-ray structure of RU486 bound to the progesterone receptor in a destabilized agonistic conformation. J Biol Chem. 2009 Jul 17;284(29):19572-9. Epub 2009 Apr 16. PMID:19372222 doi:http://dx.doi.org/10.1074/jbc.M109.007872

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Michal Harel, Alexander Berchansky

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