Proteasome

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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* Proteasome 20S particle
+
* Proteasome 20S core
**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br />
**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br />
 +
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br />
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br />
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[5fg7]], [[5fg9]], [[5fga]] - y20S core (mutant)<br />
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[5fg7]], [[5fg9]], [[5fga]] - y20S core (mutant)<br />
-
**[[4r3o]], [[5le5]], [[5lex]] – h20S – human<br />
+
**[[4r3o]], [[5le5]], [[5lex]] – h20S core – human<br />
-
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
+
**[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]], [[6bdf]], [[5vy4]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br />
-
**[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br />
+
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />
**[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br />
**[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br />
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**[[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br />
**[[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br />
**[[5lzp]] - Mt20S subunits a+b + BPA - Cryo EM<br />
**[[5lzp]] - Mt20S subunits a+b + BPA - Cryo EM<br />
 +
**[[6bgo]], [[6bgl]] – Mt20S + activator<br />
*Proteasome 20S+inhibitor
*Proteasome 20S+inhibitor
-
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]] – y20S core+inhibitor<br />
+
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]], [[6gop]] – y20S core+inhibitor<br />
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]] – y20S (mutant) + inhibitor<br />
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]] – y20S (mutant) + inhibitor<br />
**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br />
**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br />
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**[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]] - h20S + inhibitor<br />
**[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]] - h20S + inhibitor<br />
**[[5a0q]] - h20S + substrate analog<br />
**[[5a0q]] - h20S + substrate analog<br />
 +
**[[6avo]] – h20S core + inhibitor<br />
**[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br />
**[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br />
**[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br />
**[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br />
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**[[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br />
**[[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br />
**[[3fp9]] – MtATPase chains A-L<br />
**[[3fp9]] – MtATPase chains A-L<br />
-
**[[1j2p]] – Af α subunit<br />
+
**[[1j2p]] – AfPRTS α subunit<br />
-
**[[2jay]] – Mt β subunit<br />
+
**[[2jay]] – MtPRTS β subunit<br />
 +
**[[5nyw]] – PRTS β subunit – ''Yersinia bercovieri''<br />
**[[2kqz]], [[2kr0]] – hPRTS ubiquitin receptor domain
**[[2kqz]], [[2kr0]] – hPRTS ubiquitin receptor domain
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**[[3aji]] - mPRTS subunit 10 + subunit 4<br />
**[[3aji]] - mPRTS subunit 10 + subunit 4<br />
**[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br />
**[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br />
 +
**[[5ln1]] - yPRTS subunit RPN10 + polyubiquitin<br />
**[[4ady]] - yPRTS subunit RPN2<br />
**[[4ady]] - yPRTS subunit RPN2<br />
**[[3vlf]] - yPRTS subunit 7 + DNA mismatch repair protein<br />
**[[3vlf]] - yPRTS subunit 7 + DNA mismatch repair protein<br />
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**[[2z4d]] - yPRTS subunit RPN13<br />
**[[2z4d]] - yPRTS subunit RPN13<br />
**[[3vl1]] - yPRTS subunit RPN14 (mutant)<br />
**[[3vl1]] - yPRTS subunit RPN14 (mutant)<br />
-
**[[4o8x]], [[4o8y]] - yPRTS subunit RPN8 + RPN11<br />
+
**[[4o8x]], [[4o8y]], [[5w83]], [[4owp]] - yPRTS subunit RPN8 + RPN11<br />
**[[4ocl]], [[4ocm]], [[4ocn]] - yPRTS subunit RPN8 + RPN11 + nanobody<br />
**[[4ocl]], [[4ocm]], [[4ocn]] - yPRTS subunit RPN8 + RPN11 + nanobody<br />
-
**[[3t5v]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br />
+
**[[5u4p]] - yPRTS subunit RPN8 + RPN11 + S31<br />
 +
**[[3t5v]], [[5l3t]], [[5g5p]], [[4trq]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br /
**[[2z59]] - mPRTS subunit RPN13+ubiquitin<br />
**[[2z59]] - mPRTS subunit RPN13+ubiquitin<br />
-
**[[3txm]], [[3txn]] – PRTS subunit P42B – ''Drosophila melanogaster''
+
**[[3txm]], [[3txn]] – PRTS subunit P42B – ''Drosophila melanogaster''<br />
-
 
+
**[[5ubp]] - yPRTS subunit SEM1 + nuclear mRNA export protein THP1 + leucine permease transcriptional regulator<br />
*Proteasome 26S particle
*Proteasome 26S particle
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**[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]] - hPRTS - Cryo EM<br />
**[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]] - hPRTS - Cryo EM<br />
**[[5m32]] - hPRTS + inhibitor - Cryo EM<br />
**[[5m32]] - hPRTS + inhibitor - Cryo EM<br />
 +
**[[6epf]], [[6epe]], [[6epd]], [[6epc]] – PRTS – rat - Cryo EM<br />
 +
**[[5vhs]], [[5vhr]], [[5vhq]], [[5vhp]], [[5vho]], [[5vhn]], [[5vhm]], [[5vhj]], [[5vhi]], [[5vhh]], [[5vhf]], [[5vgz]], [[5vft]], [[5vfr]], [[5vfo]] – hPRTS - Cryo EM<br />
 +
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:45, 28 August 2018

Yeast proteasome 20S core complex with salinosporamide derivative, 3gpt

Drag the structure with the mouse to rotate

3D Structures of Proteasome

Updated on 28-August-2018

References

  1. ↑ Saeki Y, Tanaka K. Assembly and function of the proteasome. Methods Mol Biol. 2012;832:315-37. doi: 10.1007/978-1-61779-474-2_22. PMID:22350895 doi:http://dx.doi.org/10.1007/978-1-61779-474-2_22
  2. ↑ Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem. 1996;65:801-47. PMID:8811196 doi:http://dx.doi.org/10.1146/annurev.bi.65.070196.004101

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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