This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Proteasome
From Proteopedia
(Difference between revisions)
| Line 16: | Line 16: | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | * Proteasome 20S | + | * Proteasome 20S core |
**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br /> | **[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br /> | ||
| + | **[[3mka]], [[3hfa]] – Mt20S core (mutant)<br /> | ||
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br /> | **[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br /> | ||
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[5fg7]], [[5fg9]], [[5fga]] - y20S core (mutant)<br /> | **[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[5fg7]], [[5fg9]], [[5fga]] - y20S core (mutant)<br /> | ||
| - | **[[4r3o]], [[5le5]], [[5lex]] – h20S – human<br /> | + | **[[4r3o]], [[5le5]], [[5lex]] – h20S core – human<br /> |
| - | **[[ | + | **[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]], [[6bdf]], [[5vy4]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br /> |
| - | + | ||
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br /> | **[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br /> | ||
**[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br /> | **[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br /> | ||
| Line 38: | Line 38: | ||
**[[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br /> | **[[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br /> | ||
**[[5lzp]] - Mt20S subunits a+b + BPA - Cryo EM<br /> | **[[5lzp]] - Mt20S subunits a+b + BPA - Cryo EM<br /> | ||
| + | **[[6bgo]], [[6bgl]] – Mt20S + activator<br /> | ||
*Proteasome 20S+inhibitor | *Proteasome 20S+inhibitor | ||
| - | **[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]] – y20S core+inhibitor<br /> | + | **[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]], [[6gop]] – y20S core+inhibitor<br /> |
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]] – y20S (mutant) + inhibitor<br /> | **[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]] – y20S (mutant) + inhibitor<br /> | ||
**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br /> | **[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br /> | ||
| Line 66: | Line 67: | ||
**[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]] - h20S + inhibitor<br /> | **[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]] - h20S + inhibitor<br /> | ||
**[[5a0q]] - h20S + substrate analog<br /> | **[[5a0q]] - h20S + substrate analog<br /> | ||
| + | **[[6avo]] – h20S core + inhibitor<br /> | ||
**[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br /> | **[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br /> | ||
**[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br /> | **[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br /> | ||
| Line 73: | Line 75: | ||
**[[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br /> | **[[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br /> | ||
**[[3fp9]] – MtATPase chains A-L<br /> | **[[3fp9]] – MtATPase chains A-L<br /> | ||
| - | **[[1j2p]] – | + | **[[1j2p]] – AfPRTS α subunit<br /> |
| - | **[[2jay]] – | + | **[[2jay]] – MtPRTS β subunit<br /> |
| + | **[[5nyw]] – PRTS β subunit – ''Yersinia bercovieri''<br /> | ||
**[[2kqz]], [[2kr0]] – hPRTS ubiquitin receptor domain | **[[2kqz]], [[2kr0]] – hPRTS ubiquitin receptor domain | ||
| Line 96: | Line 99: | ||
**[[3aji]] - mPRTS subunit 10 + subunit 4<br /> | **[[3aji]] - mPRTS subunit 10 + subunit 4<br /> | ||
**[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br /> | **[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br /> | ||
| + | **[[5ln1]] - yPRTS subunit RPN10 + polyubiquitin<br /> | ||
**[[4ady]] - yPRTS subunit RPN2<br /> | **[[4ady]] - yPRTS subunit RPN2<br /> | ||
**[[3vlf]] - yPRTS subunit 7 + DNA mismatch repair protein<br /> | **[[3vlf]] - yPRTS subunit 7 + DNA mismatch repair protein<br /> | ||
| Line 104: | Line 108: | ||
**[[2z4d]] - yPRTS subunit RPN13<br /> | **[[2z4d]] - yPRTS subunit RPN13<br /> | ||
**[[3vl1]] - yPRTS subunit RPN14 (mutant)<br /> | **[[3vl1]] - yPRTS subunit RPN14 (mutant)<br /> | ||
| - | **[[4o8x]], [[4o8y]] - yPRTS subunit RPN8 + RPN11<br /> | + | **[[4o8x]], [[4o8y]], [[5w83]], [[4owp]] - yPRTS subunit RPN8 + RPN11<br /> |
**[[4ocl]], [[4ocm]], [[4ocn]] - yPRTS subunit RPN8 + RPN11 + nanobody<br /> | **[[4ocl]], [[4ocm]], [[4ocn]] - yPRTS subunit RPN8 + RPN11 + nanobody<br /> | ||
| - | **[[3t5v]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br / | + | **[[5u4p]] - yPRTS subunit RPN8 + RPN11 + S31<br /> |
| + | **[[3t5v]], [[5l3t]], [[5g5p]], [[4trq]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br / | ||
**[[2z59]] - mPRTS subunit RPN13+ubiquitin<br /> | **[[2z59]] - mPRTS subunit RPN13+ubiquitin<br /> | ||
| - | **[[3txm]], [[3txn]] – PRTS subunit P42B – ''Drosophila melanogaster'' | + | **[[3txm]], [[3txn]] – PRTS subunit P42B – ''Drosophila melanogaster''<br /> |
| - | + | **[[5ubp]] - yPRTS subunit SEM1 + nuclear mRNA export protein THP1 + leucine permease transcriptional regulator<br /> | |
*Proteasome 26S particle | *Proteasome 26S particle | ||
| Line 120: | Line 125: | ||
**[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]] - hPRTS - Cryo EM<br /> | **[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]] - hPRTS - Cryo EM<br /> | ||
**[[5m32]] - hPRTS + inhibitor - Cryo EM<br /> | **[[5m32]] - hPRTS + inhibitor - Cryo EM<br /> | ||
| + | **[[6epf]], [[6epe]], [[6epd]], [[6epc]] – PRTS – rat - Cryo EM<br /> | ||
| + | **[[5vhs]], [[5vhr]], [[5vhq]], [[5vhp]], [[5vho]], [[5vhn]], [[5vhm]], [[5vhj]], [[5vhi]], [[5vhh]], [[5vhf]], [[5vgz]], [[5vft]], [[5vfr]], [[5vfo]] – hPRTS - Cryo EM<br /> | ||
| + | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:45, 28 August 2018
| |||||||||||
3D Structures of Proteasome
Updated on 28-August-2018
References
- ↑ Saeki Y, Tanaka K. Assembly and function of the proteasome. Methods Mol Biol. 2012;832:315-37. doi: 10.1007/978-1-61779-474-2_22. PMID:22350895 doi:http://dx.doi.org/10.1007/978-1-61779-474-2_22
- ↑ Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem. 1996;65:801-47. PMID:8811196 doi:http://dx.doi.org/10.1146/annurev.bi.65.070196.004101
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
