5omi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of GP2 from Lassa virus in a post fusion conformation== | |
| - | + | <StructureSection load='5omi' size='340' side='right' caption='[[5omi]], [[Resolution|resolution]] 2.56Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5omi]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OMI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5omi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5omi OCA], [http://pdbe.org/5omi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5omi RCSB], [http://www.ebi.ac.uk/pdbsum/5omi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5omi ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A0A097F3Y1_9VIRU A0A097F3Y1_9VIRU]] Glycoprotein G1: interacts with the host receptor.[HAMAP-Rule:MF_04084] Glycoprotein G2: class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversible conformational changes induced upon acidification in the endosome.[HAMAP-Rule:MF_04084] Stable signal peptide (SSP): cleaved and functions as a signal peptide. In addition, it is also retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.[HAMAP-Rule:MF_04084] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Diskin, R]] | [[Category: Diskin, R]] | ||
[[Category: Shulman, A]] | [[Category: Shulman, A]] | ||
| + | [[Category: Viral glycoprotein]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 07:16, 29 August 2018
Crystal structure of GP2 from Lassa virus in a post fusion conformation
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