Cruzain
From Proteopedia
(Difference between revisions)
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<StructureSection load='1me3' size='350' side='right' caption='Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry [[1me3]])' scene='51/517378/Cv/1'> | <StructureSection load='1me3' size='350' side='right' caption='Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry [[1me3]])' scene='51/517378/Cv/1'> | ||
| - | '''Cruzain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID:10997902</ref> | + | '''Cruzain''' or '''cruzapain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID:10997902</ref> |
== Relevance == | == Relevance == | ||
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[[1ewl]], [[1ewm]] – Cru catalytic domain + methylbutane inhibitor<br /> | [[1ewl]], [[1ewm]] – Cru catalytic domain + methylbutane inhibitor<br /> | ||
[[1ewp]] - Cru catalytic domain + MOR-Leu-HPQ<br /> | [[1ewp]] - Cru catalytic domain + MOR-Leu-HPQ<br /> | ||
| + | [[4w5b]], [[4xui]], [[4qh6]], [[4pi3]], [[4klb]], [[3lxs]], [[3kku]], [[3i06]], [[2oz2]], [[1u9q]] – TcPRO + inhibitor <br /> | ||
| + | [[4w5c]], [[3iut]], [[3hd3]] – TcPRO (mutant) + inhibitor <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 08:40, 2 September 2018
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3D structures of cruzain
Updated on 02-September-2018
1aim, 2aim, 1me3, 1me4 – Cru catalytic domain + methylketone inhibitor – Trypanosoma cruzi
1f29, 1f2a, 1f2b, 1f2c, 1ewo, 3lxs - Cru catalytic domain + vinyl sulfone derived inhibitor
1ewl, 1ewm – Cru catalytic domain + methylbutane inhibitor
1ewp - Cru catalytic domain + MOR-Leu-HPQ
4w5b, 4xui, 4qh6, 4pi3, 4klb, 3lxs, 3kku, 3i06, 2oz2, 1u9q – TcPRO + inhibitor
4w5c, 3iut, 3hd3 – TcPRO (mutant) + inhibitor
References
- ↑ Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure. 2000 Aug 15;8(8):831-40. PMID:10997902
- ↑ Huang L, Brinen LS, Ellman JA. Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain. Bioorg Med Chem. 2003 Jan 2;11(1):21-9. PMID:12467703
