Retinoblastoma-binding protein

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* '''RBBP1''' regulates transcriptional activity<ref>PMID:8414517</ref>.<br />
* '''RBBP1''' regulates transcriptional activity<ref>PMID:8414517</ref>.<br />
* '''RBBP2''' demethylates histone H3 at lysine 4.<br />
* '''RBBP2''' demethylates histone H3 at lysine 4.<br />
 +
* '''RBBP2 homolog''' see KDM5B in [[Lysine-specific histone demethylase]].<br />
* '''RBBP5''' is involved in methylation and dimethylation of histone H3.<br />
* '''RBBP5''' is involved in methylation and dimethylation of histone H3.<br />
* '''RBBP6''' promotes p53 degradation<ref>PMID:21676486</ref>.<br />
* '''RBBP6''' promotes p53 degradation<ref>PMID:21676486</ref>.<br />
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**[[3gl6]] - hRBBP2 C terminal PHD zinc finger + histone H3 N terminal
**[[3gl6]] - hRBBP2 C terminal PHD zinc finger + histone H3 N terminal
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*Retinoblastoma-binding protein 4
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*Retinoblastoma-binding protein 4 or histone-binding protein RBBP4
**[[3gfc]] – hRBBP4<br />
**[[3gfc]] – hRBBP4<br />
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**[[4pby]], [[4pbz]], [[4pc0]] – hRBBP4 + metastasis-associated protein<br />
**[[4pby]], [[4pbz]], [[4pc0]] – hRBBP4 + metastasis-associated protein<br />
**[[4r7a]] – hRBBP4 + PHD protein 6 peptide<br />
**[[4r7a]] – hRBBP4 + PHD protein 6 peptide<br />
-
**[[5fxy]] – hRBBP4 + MTA1 protein <br />
+
**[[6bw4]] – hRBBP4 + Prdm16 peptide<br />
 +
**[[6bw3]] – hRBBP4 + Mds1 peptide<br />
 +
**[[5y1u]] – hRBBP4 + Aebp2 peptide<br />
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**[[5xxq]] – hRBBP4 + Znf827 peptide<br />
 +
**[[5wak]] – hRBBP4 + Suz12 peptide<br />
 +
**[[5vtb]] – hRBBP4 + Bcl11A peptide<br />
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**[[5xwr]] – hRBBP4 + peptide<br />
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**[[5fxy]], [[6g16]] – hRBBP4 + MTA1 protein <br />
 +
**[[5wai]] – hRBBP4 + Suz12 + Jumonji + Aebp2 <br />
 +
**[[6c23]] – hRBBP4 + Suz12 + Jumonji + Ezh2 + Eed + Jarid2 + Aebp2 – Cryo EM <br />
*Retinoblastoma-binding protein 6
*Retinoblastoma-binding protein 6

Revision as of 08:40, 3 September 2018

Human retinoblastoma-binding protein 7 (green) complex with histone H4 helix (magenta) and As ion (purple) 3cfs

Drag the structure with the mouse to rotate

3D structures of retinoblastoma-binding protein

Updated on 03-September-2018

References

  1. Woitach JT, Zhang M, Niu CH, Thorgeirsson SS. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Nat Genet. 1998 Aug;19(4):371-4. PMID:9697699 doi:http://dx.doi.org/10.1038/1258
  2. Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D, et al.. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene. 1993 Nov;8(11):3149-56. PMID:8414517
  3. Motadi LR, Bhoola KD, Dlamini Z. Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer. Immunobiology. 2011 Oct;216(10):1065-73. doi: 10.1016/j.imbio.2011.05.004. Epub, 2011 May 17. PMID:21676486 doi:http://dx.doi.org/10.1016/j.imbio.2011.05.004
  4. Yang J, Kiefer S, Rauchman M. Characterization of the gene encoding mouse retinoblastoma binding protein-7, a component of chromatin-remodeling complexes. Genomics. 2002 Oct;80(4):407-15. PMID:12376095
  5. Vorobiev SM, Huang YJ, Seetharaman J, Xiao R, Acton TB, Montelione GT, Tong L. Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers. Protein Pept Lett. 2012 Feb;19(2):194-7. PMID:21933118
  6. Murzina NV, Pei XY, Zhang W, Sparkes M, Vicente-Garcia J, Pratap JV, McLaughlin SH, Ben-Shahar TR, Verreault A, Luisi BF, Laue ED. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure. 2008 Jul;16(7):1077-85. Epub 2008 Jun 19. PMID:18571423 doi:http://dx.doi.org/10.1016/j.str.2008.05.006

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