2pl4
From Proteopedia
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|PDB= 2pl4 |SIZE=350|CAPTION= <scene name='initialview01'>2pl4</scene>, resolution 1.65Å | |PDB= 2pl4 |SIZE=350|CAPTION= <scene name='initialview01'>2pl4</scene>, resolution 1.65Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[115d|115D]], [[1vj4|1VJ4]], [[2pkv|2PKV]], [[2pl8|2PL8]], [[2plb|2PLB]], [[2plo|2PLO]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pl4 OCA], [http://www.ebi.ac.uk/pdbsum/2pl4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pl4 RCSB]</span> | ||
}} | }} | ||
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[[Category: high-pressure]] | [[Category: high-pressure]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:37:23 2008'' |
Revision as of 01:37, 31 March 2008
| |||||||
| , resolution 1.65Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Related: | 115D, 1VJ4, 2PKV, 2PL8, 2PLB, 2PLO
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
D-(GGTATACC) under 0.55 GPa hydrostatic pressure
Overview
The behaviour of the d(GGTATACC) oligonucleotide has been investigated by X-ray crystallography at 295 K in the range from ambient pressure to 2 GPa (approximately 20,000 atm). Four 3D-structures of the A-DNA form (at ambient pressure, 0.55, 1.09 and 1.39 GPa) were refined at 1.60 or 1.65 A resolution. In addition to the diffraction pattern of the A-form, the broad meridional streaks previously explained by occluded B-DNA octamers within the channels of the crystalline A-form matrix were observed up to at least 2 GPa. This work highlights an important property of nucleic acids, their capability to withstand very high pressures, while keeping in such conditions a nearly invariant geometry of base pairs that store and carry genetic information. The double-helix base-paired architecture behaves as a molecular spring, which makes it especially adapted to very harsh conditions. These features may have contributed to the emergence of a RNA World at prebiotic stage.
About this Structure
2PL4 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:17617642
Page seeded by OCA on Mon Mar 31 04:37:23 2008
