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| - | | + | #REDIRECT [[6mal]] This PDB entry is obsolete and replaced by 6mal |
| - | ==Structure of human Nocturnin C-terminal domain==
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| - | <StructureSection load='6dip' size='340' side='right' caption='[[6dip]], [[Resolution|resolution]] 2.60Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6dip]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DIP FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dip OCA], [http://pdbe.org/6dip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dip RCSB], [http://www.ebi.ac.uk/pdbsum/6dip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dip ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/NOCT_HUMAN NOCT_HUMAN]] Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Du, J]]
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| - | [[Category: Estrella, M A]]
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| - | [[Category: Korennykh, A]]
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| - | [[Category: Ccr4]]
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| - | [[Category: Ccrn4l]]
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| - | [[Category: Hydrolase]]
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| - | [[Category: Noct]]
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| - | [[Category: Nocturnin]]
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Current revision
- REDIRECT 6mal This PDB entry is obsolete and replaced by 6mal
