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5yb1

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'''Unreleased structure'''
 
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The entry 5yb1 is ON HOLD until Sep 02 2019
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==Structure and function of human serum albumin-metal agent complex==
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<StructureSection load='5yb1' size='340' side='right' caption='[[5yb1]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5yb1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YB1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8ZR:~{N},~{N},12-trimethyl-3$l^{3}-thia-1$l^{4},5,6$l^{4}-triaza-2$l^{3}-cupratricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,6,9,11-pentaen-4-amine'>8ZR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yb1 OCA], [http://pdbe.org/5yb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yb1 RCSB], [http://www.ebi.ac.uk/pdbsum/5yb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yb1 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gou, Y]]
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[[Category: Wang, J]]
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[[Category: Wang, T]]
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[[Category: Yang, F]]
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[[Category: Zhang, Z L]]
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[[Category: Albumin]]
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[[Category: Drug carrier]]
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[[Category: Lipid binding protein]]
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[[Category: Metal complex]]
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[[Category: Pro-drug]]
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[[Category: Target therapy]]

Revision as of 10:00, 5 September 2018

Structure and function of human serum albumin-metal agent complex

5yb1, resolution 2.62Å

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