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6edx

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m (Protected "6edx" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6edx is ON HOLD
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==Crystal Structure of SGK3 PX domain==
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<StructureSection load='6edx' size='340' side='right' caption='[[6edx]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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Authors: Chandra, M., Collins, B.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6edx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EDX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EDX FirstGlance]. <br>
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Description: Crystal Structure of SGK3 PX domain
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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[[Category: Collins, B.M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6edx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6edx OCA], [http://pdbe.org/6edx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6edx RCSB], [http://www.ebi.ac.uk/pdbsum/6edx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6edx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SGK3_HUMAN SGK3_HUMAN]] Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.<ref>PMID:12054501</ref> <ref>PMID:12397388</ref> <ref>PMID:12590200</ref> <ref>PMID:12632189</ref> <ref>PMID:12634932</ref> <ref>PMID:12650886</ref> <ref>PMID:12911626</ref> <ref>PMID:14706641</ref> <ref>PMID:15040001</ref> <ref>PMID:15044175</ref> <ref>PMID:15319523</ref> <ref>PMID:15496163</ref> <ref>PMID:15737648</ref> <ref>PMID:15845389</ref> <ref>PMID:16036218</ref> <ref>PMID:16888620</ref> <ref>PMID:17167223</ref> <ref>PMID:18005662</ref> <ref>PMID:19293151</ref> <ref>PMID:20511718</ref> <ref>PMID:21865597</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Chandra, M]]
[[Category: Chandra, M]]
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[[Category: Collins, B M]]
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[[Category: Endosome]]
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[[Category: Px domain]]
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[[Category: Sorting nexin]]
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[[Category: Trafficking]]
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[[Category: Transferase]]

Revision as of 10:10, 5 September 2018

Crystal Structure of SGK3 PX domain

6edx, resolution 2.01Å

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