6esp
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Proteome-wide analysis of phospho-regulated PDZ domain interactions== | |
| - | + | <StructureSection load='6esp' size='340' side='right' caption='[[6esp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6esp]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ESP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ESP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6esp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6esp OCA], [http://pdbe.org/6esp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6esp RCSB], [http://www.ebi.ac.uk/pdbsum/6esp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6esp ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Chi, N | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chi, N C]] | ||
| + | [[Category: Pdz]] | ||
| + | [[Category: Phosphorylation]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Scribble]] | ||
Revision as of 10:10, 5 September 2018
Proteome-wide analysis of phospho-regulated PDZ domain interactions
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