6h8t
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Papain modify by achiral Ru(II)complex== | |
| + | <StructureSection load='6h8t' size='340' side='right' caption='[[6h8t]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6h8t]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4kp9 4kp9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H8T FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YXX:CHLORO(1-{5-[DI(PYRIDIN-2-YL-KAPPAN)AMINO]PENTYL}PYRROLIDINE-2,5-DIONE)RUTHENIUM'>YXX</scene>, <scene name='pdbligand=YXZ:CHLORO[N,N-DI(PYRIDIN-2-YL-KAPPAN)PENTANE-1,5-DIAMINE]RUTHENIUM'>YXZ</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OMX:(BETAR)-BETA-HYDROXY-L-TYROSINE'>OMX</scene>, <scene name='pdbligand=TXY:3-[(5S)-4,5-DIHYDROXYCYCLOHEXA-1,3-DIEN-1-YL]-L-ALANINE'>TXY</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kp9|4kp9]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h8t OCA], [http://pdbe.org/6h8t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h8t RCSB], [http://www.ebi.ac.uk/pdbsum/6h8t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h8t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The X-ray structure of an aerated achiral Ru-papain conjugate has revealed the hydroxylation of two tyrosine residues found near the ruthenium ion. The most likely mechanism involves a ruthenium-bound superoxide as the reactive species responsible for the first hydroxylation and the resulting high valent Ru(iv)[double bond, length as m-dash]O species for the second one. | ||
| - | + | Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate.,Cherrier MV, Amara P, Talbi B, Salmain M, Fontecilla-Camps JC Metallomics. 2018 Sep 3. doi: 10.1039/c8mt00160j. PMID:30175357<ref>PMID:30175357</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6h8t" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Papain]] | ||
| + | [[Category: Amara, P]] | ||
| + | [[Category: Cherrier, M V]] | ||
| + | [[Category: Fontecilla-Camps, J C]] | ||
[[Category: Salmin, M]] | [[Category: Salmin, M]] | ||
[[Category: Talbi, B]] | [[Category: Talbi, B]] | ||
| - | [[Category: | + | [[Category: Artificial metalloenzyme hydroxylation ruthenium complex]] |
| - | [[Category: | + | [[Category: Metal binding protein]] |
| - | + | ||
Revision as of 07:25, 12 September 2018
Crystal structure of Papain modify by achiral Ru(II)complex
| |||||||||||
