5nb0
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structures of homooligomers of collagen type IV. alpha3NC1== | |
| - | + | <StructureSection load='5nb0' size='340' side='right' caption='[[5nb0]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nb0]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NB0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NB0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nb0 OCA], [http://pdbe.org/5nb0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nb0 RCSB], [http://www.ebi.ac.uk/pdbsum/5nb0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nb0 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CO4A3_HUMAN CO4A3_HUMAN]] Benign familial hematuria;Autosomal dominant Alport syndrome;Autosomal recessive Alport syndrome. Autoantibodies against the NC1 domain of alpha 3(IV) are found in Goodpasture syndrome, an autoimmune disease of lung and kidney. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CO4A3_HUMAN CO4A3_HUMAN]] Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Casino, P]] | [[Category: Casino, P]] | ||
[[Category: Marina, A]] | [[Category: Marina, A]] | ||
| + | [[Category: Non-collagenous domain of collagen type iv. a principal structural component of basement membrane]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 07:27, 12 September 2018
Crystal structures of homooligomers of collagen type IV. alpha3NC1
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