6aya
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the native full-length HIV-1 capsid protein in complex with Nup153 peptide== | |
| - | + | <StructureSection load='6aya' size='340' side='right' caption='[[6aya]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6aya]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AYA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xfx|4xfx]], [[6ay9|6ay9]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aya OCA], [http://pdbe.org/6aya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aya RCSB], [http://www.ebi.ac.uk/pdbsum/6aya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aya ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity). [[http://www.uniprot.org/uniprot/NU153_HUMAN NU153_HUMAN]] Possible DNA-binding subunit of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gres, A T]] | ||
| + | [[Category: Kirby, K A]] | ||
| + | [[Category: Sarafianos, S G]] | ||
| + | [[Category: Hexamer]] | ||
| + | [[Category: Hiv-1 capsid protein]] | ||
| + | [[Category: Nup153 complex]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 07:33, 12 September 2018
Structure of the native full-length HIV-1 capsid protein in complex with Nup153 peptide
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