6ayt
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with pyrazinylthio-DADMe-Immucillin-A== | |
| - | + | <StructureSection load='6ayt' size='340' side='right' caption='[[6ayt]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ayt]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AYT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4EH:(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(PYRAZIN-2-YLSULFANYL)METHYL]PYRROLIDIN-3-OL'>4EH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteine_nucleosidase Adenosylhomocysteine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.9 3.2.2.9] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ayt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ayt OCA], [http://pdbe.org/6ayt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ayt RCSB], [http://www.ebi.ac.uk/pdbsum/6ayt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ayt ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A0A1E7P7U4_CAMJU A0A1E7P7U4_CAMJU]] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.[SAAS:SAAS00679308] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Adenosylhomocysteine nucleosidase]] | ||
| + | [[Category: Almo, S C]] | ||
| + | [[Category: Bonanno, J B]] | ||
| + | [[Category: Ducati, R G]] | ||
| + | [[Category: Harijan, R K]] | ||
| + | [[Category: Schramm, V L]] | ||
| + | [[Category: Foodborne disease]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Mtan enzyme]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:34, 12 September 2018
Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with pyrazinylthio-DADMe-Immucillin-A
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