Lysine-specific histone demethylase
From Proteopedia
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**[[6bva]] – hKDM2B residues 888-932 + SKP1 + polyubiquitin <br /> | **[[6bva]] – hKDM2B residues 888-932 + SKP1 + polyubiquitin <br /> | ||
**[[5jh5]] – hKDM2B residues 1059-1336 + SKP1 + NSPC1 + BCor-like protein <br /> | **[[5jh5]] – hKDM2B residues 1059-1336 + SKP1 + NSPC1 + BCor-like protein <br /> | ||
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| + | *lysine-specific histone demethylase 5A or KDM5A | ||
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| + | **[[5e6h]] - hLSD5A jumonji domain<br /> | ||
| + | **[[5ivb]], [[5ivc]], [[5ive]], [[5ivf]] [[5ivj]], [[5ivv]], [[5ivy]], [[5iw0]], [[5iwf]], [[6bgu]], [[6bgv]], [[6bgw]], [[6bgx]], [[6bgy]], [[6bgz]], [[6bh1]], [[6bh0]], [[6bh2]], [[6bh3]], [[6bh4]], [[6bh5]], [[5isl]] - hLSD5A jumonji domain + inhibitor<br /> | ||
| + | **[[5v9p]], [[5v9t]] - hLSD5A + inhibitor<br /> | ||
| + | **[[5k4l]], [[5ceh]] - hLSD5A + peptide + inhibitor<br /> | ||
| + | **[[5c11]] - hLSD5A PHD domain + H3 peptide<br /> | ||
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}} | }} | ||
Revision as of 16:52, 12 September 2018
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3D structures of lysine-specific histone demethylase
Updated on 12-September-2018
References
- ↑ Chen Y, Jie W, Yan W, Zhou K, Xiao Y. Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy. Crit Rev Eukaryot Gene Expr. 2012;22(1):53-9. PMID:22339659
- ↑ Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERalpha-dependent and -independent manners. ACS Chem Biol. 2012 Jul 20;7(7):1221-31. doi: 10.1021/cb300108c. Epub 2012 May, 10. PMID:22533360 doi:http://dx.doi.org/10.1021/cb300108c
- ↑ van Essen D, Zhu Y, Saccani S. A feed-forward circuit controlling inducible NF-kappaB target gene activation by promoter histone demethylation. Mol Cell. 2010 Sep 10;39(5):750-60. doi: 10.1016/j.molcel.2010.08.010. PMID:20832726 doi:http://dx.doi.org/10.1016/j.molcel.2010.08.010
- ↑ Li X, Liu L, Yang S, Song N, Zhou X, Gao J, Yu N, Shan L, Wang Q, Liang J, Xuan C, Wang Y, Shang Y, Shi L. Histone demethylase KDM5B is a key regulator of genome stability. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7096-101. doi:, 10.1073/pnas.1324036111. Epub 2014 Apr 28. PMID:24778210 doi:http://dx.doi.org/10.1073/pnas.1324036111
- ↑ Chen Y, Yang Y, Wang F, Wan K, Yamane K, Zhang Y, Lei M. Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13956-61. Epub 2006 Sep 6. PMID:16956976
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