Ryanodine receptor

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**[[5tb0]], [[5taw]], [[5tax]], [[5tay]], [[5taz]], [[5t15]], [[5t9m]], [[5t9n]], [[5t9r]], [[5t9s]], [[5t9v]], [[5tb0]], [[5tb1]], [[5tb2]], [[5tb3]], [[5tb4]], [[5gky]], [[5gkz]], [[5gl0]], [[5gl1]] – rRyR1 + FKBP1B – Cryo EM <br />
**[[5tb0]], [[5taw]], [[5tax]], [[5tay]], [[5taz]], [[5t15]], [[5t9m]], [[5t9n]], [[5t9r]], [[5t9s]], [[5t9v]], [[5tb0]], [[5tb1]], [[5tb2]], [[5tb3]], [[5tb4]], [[5gky]], [[5gkz]], [[5gl0]], [[5gl1]] – rRyR1 + FKBP1B – Cryo EM <br />
**[[5ta3]], [[5tal]], [[5tam]], [[5tan]], [[5tap]], [[5taq]], [[5tas]], [[5tat]], [[5tau]], [[5tav]] – rRyR1 + FKBP1B + caffeine + ATP – Cryo EM <br />
**[[5ta3]], [[5tal]], [[5tam]], [[5tan]], [[5tap]], [[5taq]], [[5tas]], [[5tat]], [[5tau]], [[5tav]] – rRyR1 + FKBP1B + caffeine + ATP – Cryo EM <br />
 +
**[[6fg3]] – rRyR1 + ryanodine + ATP – Cryo EM <br />
 +
**[[6foo]] – rRyR1 + ATP – Cryo EM <br />
**[[3j8h]] – rRyR1 + FKBP12 – Cryo EM <br />
**[[3j8h]] – rRyR1 + FKBP12 – Cryo EM <br />
 +
**[[5y9v]] – RyR1 N terminal - diamondback moth <br />
-
*Ryanodine receptor 2 (Cardiac Ca+2 release channel)
+
*Ryanodine receptor 2 (Cardiac Ca+2 release channel); domains - N terminal 1-547; SPRY2 1080-1253; phosphorylation 2699-2904
-
**[[3im5]] – mRyR2 N terminal residues 1-217 – mouse <br />
+
**[[3im5]] – mRyR2 N terminal – mouse <br />
-
**[[3im6]], [[3im7]], [[4kei]], [[4kej]], [[4kek]] – mRyR2 N terminal residues 1-217 (mutant) <br />
+
**[[3im6]], [[3im7]], [[4kei]], [[4kej]], [[4kek]] – mRyR2 N terminal (mutant) <br />
-
**[[2mc2]] – mRyR2 N terminal residues 1-217 - NMR <br />
+
**[[2mc2]] – mRyR2 N terminal - NMR <br />
-
**[[3qr5]] – mRyR2 N terminal residues 1-56, 92-217 <br />
+
**[[3qr5]] – mRyR2 N terminal <br />
-
**[[4etv]] – mRyR2 phosphorylation domain residues 2699-2904 (mutant) <br />
+
**[[4etv]] – mRyR2 phosphorylation domain (mutant) <br />
-
**[[4l4h]] – mRyR2 N terminal residues 1-547 <br />
+
**[[4l4h]] – mRyR2 N terminal <br />
-
**[[4l4i]] – mRyR2 N terminal residues 1-547 (mutant) <br />
+
**[[4l4i]] – mRyR2 N terminal (mutant) <br />
-
**[[4p9i]] – mRyR2 SPRY2 domain residues 1080-1253 <br />
+
**[[4p9i]] – mRyR2 SPRY2 domain <br />
-
**[[4p9l]] – mRyR2 SPRY2 domain residues 1080-1253 (mutant)<br />
+
**[[4p9l]], [[5vsn]] – mRyR2 SPRY2 domain (mutant)<br />
-
**[[4jkq]] – hRyR2 N terminal residues 1-606 - human <br />
+
**[[4jkq]] – hRyR2 N terminal - human <br />
**[[5go9]], [[5goa]] – RyR2 – pig - Cryo EM <br />
**[[5go9]], [[5goa]] – RyR2 – pig - Cryo EM <br />
**[[5l1d]] – rRyR2 + FKBP12 – Cryo EM <br />
**[[5l1d]] – rRyR2 + FKBP12 – Cryo EM <br />

Revision as of 22:03, 14 September 2018

Rabbit ryanodine receptor 1 N-terminal (PDB code 2xoa)

Drag the structure with the mouse to rotate

3D Structures of ryanodine receptor

Updated on 14-September-2018

References

  1. Fill M, Copello JA. Ryanodine receptor calcium release channels. Physiol Rev. 2002 Oct;82(4):893-922. PMID:12270947 doi:http://dx.doi.org/10.1152/physrev.00013.2002
  2. Sato K, Roesl C, Pollock N, Stowell KM. Skeletal muscle ryanodine receptor mutations associated with malignant hyperthermia showed enhanced intensity and sensitivity to triggering drugs when expressed in human embryonic kidney cells. Anesthesiology. 2013 Jul;119(1):111-8. doi: 10.1097/ALN.0b013e31828cebfe. PMID:23459219 doi:http://dx.doi.org/10.1097/ALN.0b013e31828cebfe
  3. McCarthy TV, Quane KA, Lynch PJ. Ryanodine receptor mutations in malignant hyperthermia and central core disease. Hum Mutat. 2000;15(5):410-7. PMID:10790202 doi:<410::AID-HUMU2>3.0.CO;2-D http://dx.doi.org/10.1002/(SICI)1098-1004(200005)15:5<410::AID-HUMU2>3.0.CO;2-D
  4. Tung CC, Lobo PA, Kimlicka L, Van Petegem F. The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule. Nature. 2010 Nov 3. PMID:21048710 doi:10.1038/nature09471

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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