Ryanodine receptor
From Proteopedia
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**[[5tb0]], [[5taw]], [[5tax]], [[5tay]], [[5taz]], [[5t15]], [[5t9m]], [[5t9n]], [[5t9r]], [[5t9s]], [[5t9v]], [[5tb0]], [[5tb1]], [[5tb2]], [[5tb3]], [[5tb4]], [[5gky]], [[5gkz]], [[5gl0]], [[5gl1]] – rRyR1 + FKBP1B – Cryo EM <br /> | **[[5tb0]], [[5taw]], [[5tax]], [[5tay]], [[5taz]], [[5t15]], [[5t9m]], [[5t9n]], [[5t9r]], [[5t9s]], [[5t9v]], [[5tb0]], [[5tb1]], [[5tb2]], [[5tb3]], [[5tb4]], [[5gky]], [[5gkz]], [[5gl0]], [[5gl1]] – rRyR1 + FKBP1B – Cryo EM <br /> | ||
**[[5ta3]], [[5tal]], [[5tam]], [[5tan]], [[5tap]], [[5taq]], [[5tas]], [[5tat]], [[5tau]], [[5tav]] – rRyR1 + FKBP1B + caffeine + ATP – Cryo EM <br /> | **[[5ta3]], [[5tal]], [[5tam]], [[5tan]], [[5tap]], [[5taq]], [[5tas]], [[5tat]], [[5tau]], [[5tav]] – rRyR1 + FKBP1B + caffeine + ATP – Cryo EM <br /> | ||
| + | **[[6fg3]] – rRyR1 + ryanodine + ATP – Cryo EM <br /> | ||
| + | **[[6foo]] – rRyR1 + ATP – Cryo EM <br /> | ||
**[[3j8h]] – rRyR1 + FKBP12 – Cryo EM <br /> | **[[3j8h]] – rRyR1 + FKBP12 – Cryo EM <br /> | ||
| + | **[[5y9v]] – RyR1 N terminal - diamondback moth <br /> | ||
| - | *Ryanodine receptor 2 (Cardiac Ca+2 release channel) | + | *Ryanodine receptor 2 (Cardiac Ca+2 release channel); domains - N terminal 1-547; SPRY2 1080-1253; phosphorylation 2699-2904 |
| - | **[[3im5]] – mRyR2 N terminal | + | **[[3im5]] – mRyR2 N terminal – mouse <br /> |
| - | **[[3im6]], [[3im7]], [[4kei]], [[4kej]], [[4kek]] – mRyR2 N terminal | + | **[[3im6]], [[3im7]], [[4kei]], [[4kej]], [[4kek]] – mRyR2 N terminal (mutant) <br /> |
| - | **[[2mc2]] – mRyR2 N terminal | + | **[[2mc2]] – mRyR2 N terminal - NMR <br /> |
| - | **[[3qr5]] – mRyR2 N terminal | + | **[[3qr5]] – mRyR2 N terminal <br /> |
| - | **[[4etv]] – mRyR2 phosphorylation domain | + | **[[4etv]] – mRyR2 phosphorylation domain (mutant) <br /> |
| - | **[[4l4h]] – mRyR2 N terminal | + | **[[4l4h]] – mRyR2 N terminal <br /> |
| - | **[[4l4i]] – mRyR2 N terminal | + | **[[4l4i]] – mRyR2 N terminal (mutant) <br /> |
| - | **[[4p9i]] – mRyR2 SPRY2 domain | + | **[[4p9i]] – mRyR2 SPRY2 domain <br /> |
| - | **[[4p9l]] – mRyR2 SPRY2 domain | + | **[[4p9l]], [[5vsn]] – mRyR2 SPRY2 domain (mutant)<br /> |
| - | **[[4jkq]] – hRyR2 N terminal | + | **[[4jkq]] – hRyR2 N terminal - human <br /> |
**[[5go9]], [[5goa]] – RyR2 – pig - Cryo EM <br /> | **[[5go9]], [[5goa]] – RyR2 – pig - Cryo EM <br /> | ||
**[[5l1d]] – rRyR2 + FKBP12 – Cryo EM <br /> | **[[5l1d]] – rRyR2 + FKBP12 – Cryo EM <br /> | ||
Revision as of 22:03, 14 September 2018
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3D Structures of ryanodine receptor
Updated on 14-September-2018
References
- ↑ Fill M, Copello JA. Ryanodine receptor calcium release channels. Physiol Rev. 2002 Oct;82(4):893-922. PMID:12270947 doi:http://dx.doi.org/10.1152/physrev.00013.2002
- ↑ Sato K, Roesl C, Pollock N, Stowell KM. Skeletal muscle ryanodine receptor mutations associated with malignant hyperthermia showed enhanced intensity and sensitivity to triggering drugs when expressed in human embryonic kidney cells. Anesthesiology. 2013 Jul;119(1):111-8. doi: 10.1097/ALN.0b013e31828cebfe. PMID:23459219 doi:http://dx.doi.org/10.1097/ALN.0b013e31828cebfe
- ↑ McCarthy TV, Quane KA, Lynch PJ. Ryanodine receptor mutations in malignant hyperthermia and central core disease. Hum Mutat. 2000;15(5):410-7. PMID:10790202 doi:<410::AID-HUMU2>3.0.CO;2-D http://dx.doi.org/10.1002/(SICI)1098-1004(200005)15:5<410::AID-HUMU2>3.0.CO;2-D
- ↑ Tung CC, Lobo PA, Kimlicka L, Van Petegem F. The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule. Nature. 2010 Nov 3. PMID:21048710 doi:10.1038/nature09471

