Protein phosphatase

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<StructureSection load='' size='350' side='right' scene='54/540142/Cv/1' caption='Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin and sulfate [[3k7v]]'>
<StructureSection load='' size='350' side='right' scene='54/540142/Cv/1' caption='Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin and sulfate [[3k7v]]'>
== Function ==
== Function ==
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'''Protein phosphatases''' (PP) regulate protein phosphorylation and thus are key in intracellular signal transduction processes.<br />
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'''Protein phosphatases''' (PP) or '''serine/threonine protein phosphatase''' regulate protein phosphorylation and thus are key in intracellular signal transduction processes.<br />
* '''PP1''' is a serine/threonine phosphatase and is a key component of the insulin signaling pathway<ref>PMID:9609113</ref>.<br />
* '''PP1''' is a serine/threonine phosphatase and is a key component of the insulin signaling pathway<ref>PMID:9609113</ref>.<br />
* '''PP2A''' targets proteins in the oncogenic signaling pathways<ref>PMID:11812651</ref>. For PP2A see also [[HEAT Repeat]].<br />
* '''PP2A''' targets proteins in the oncogenic signaling pathways<ref>PMID:11812651</ref>. For PP2A see also [[HEAT Repeat]].<br />
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**[[2ie3]], [[2ie4]], [[2npp]], [[2nyl]], [[2nym]] – hPP2A catalytic + regulatory subunit + tumor-inducing toxin<br />
**[[2ie3]], [[2ie4]], [[2npp]], [[2nyl]], [[2nym]] – hPP2A catalytic + regulatory subunit + tumor-inducing toxin<br />
**[[3c5w]] – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase<br />
**[[3c5w]] – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase<br />
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*Protein phosphatase 2B See [[Calcineurin]]
*Protein phosphatase 2C
*Protein phosphatase 2C
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**[[4yzh]] – AtPP2C (mutant) + chlorophyll-binding protein peptide<br />
**[[4yzh]] – AtPP2C (mutant) + chlorophyll-binding protein peptide<br />
**[[3ujg]] - AtPP2C + SRK2E<br />
**[[3ujg]] - AtPP2C + SRK2E<br />
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*Protein phosphatase 4
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**[[4wsf]] – PP4 regulatory subunit + Cenp-C – ''Drosophila melanogaster''<br />
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*Protein phosphatase 5
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**[[1wao]] – hPP5 + Mn<br />
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**[[5muf]] – hPP5 <br />
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**[[1a17]] – hPP5 protein-interacting domain<br />
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**[[2bug]] – hPP5 protein-interacting domain (mutant) + Hsp90 peptide - NMR<br />
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**[[1s95]], [[3h60]] – hPP5 catalytic domain + Mn<br />
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**[[3h61]], [[3h62]], [[3h63]], [[3h64]], [[3h66]], [[3h67]], [[3h68]], [[3h69]], [[4zvz]], [[4zx2]], [[4zvz]], [[4zx2]] – hPP5 catalytic domain + inhibitor + Mn<br />
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**[[5hpe]] – hPP5 catalytic domain/Hsp90 peptide + Mn<br />
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**[[4ja7]], [[4ja9]] - rPP5 catalytic domain + inhibitor <br />
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**[[3icf]] - yPP5 catalytic domain + Fe - yeast<br />
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**[[5jjt]] – AtPP5 + Ni<br />
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*Protein phosphatase
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**[[1g5b]] – PP + Mn – Enterobacteria phage λ<br />
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**[[2pk0]] – PP + Mg – ''Streptococcus agalactiae''<br />
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**[[2cm1]] – PP + Mn – ''Mycobacterium tuberculosis''<br />
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**[[3pu9]] – PP + Mg – ''Sphaerobacter thermophilus''<br />
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**[[5f1m]] – PP Stp1 + Mn – ''Staphylococcus aureus''<br />
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**[[5jpf]] – PP Z1 + microcystin-LR + Mn – ''Candida albicans''<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 21:50, 18 September 2018

Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin and sulfate 3k7v

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3D Structures of protein phosphatase

Updated on 18-September-2018

References

  1. ↑ Ragolia L, Begum N. Protein phosphatase-1 and insulin action. Mol Cell Biochem. 1998 May;182(1-2):49-58. PMID:9609113
  2. ↑ Resjo S, Goransson O, Harndahl L, Zolnierowicz S, Manganiello V, Degerman E. Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Cell Signal. 2002 Mar;14(3):231-8. PMID:11812651
  3. ↑ Lipinszki Z, Lefevre S, Savoian MS, Singleton MR, Glover DM, Przewloka MR. Centromeric binding and activity of Protein Phosphatase 4. Nat Commun. 2015 Jan 6;6:5894. doi: 10.1038/ncomms6894. PMID:25562660 doi:http://dx.doi.org/10.1038/ncomms6894
  4. ↑ Chinkers M. Protein phosphatase 5 in signal transduction. Trends Endocrinol Metab. 2001 Jan-Feb;12(1):28-32. PMID:11137038
  5. ↑ Perrotti D, Neviani P. Protein phosphatase 2A: a target for anticancer therapy. Lancet Oncol. 2013 May;14(6):e229-38. doi: 10.1016/S1470-2045(12)70558-2. PMID:23639323 doi:http://dx.doi.org/10.1016/S1470-2045(12)70558-2
  6. ↑ Rudrabhatla P, Pant HC. Role of protein phosphatase 2A in Alzheimer's disease. Curr Alzheimer Res. 2011 Sep;8(6):623-32. PMID:21605044
  7. ↑ Huhn J, Jeffrey PD, Larsen K, Rundberget T, Rise F, Cox NR, Arcus V, Shi Y, Miles CO. A structural basis for the reduced toxicity of dinophysistoxin-2. Chem Res Toxicol. 2009 Nov;22(11):1782-6. PMID:19916524 doi:10.1021/tx9001622
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