5y9z
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of rat hematopoietic prostaglandin D synthase== | |
| - | + | <StructureSection load='5y9z' size='340' side='right' caption='[[5y9z]], [[Resolution|resolution]] 1.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5y9z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y9Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9z OCA], [http://pdbe.org/5y9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y9z RCSB], [http://www.ebi.ac.uk/pdbsum/5y9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9z ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HPGDS_RAT HPGDS_RAT]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10871602</ref> <ref>PMID:11672424</ref> <ref>PMID:16547010</ref> <ref>PMID:9323136</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aritake, K]] | ||
| + | [[Category: Furubayashi, N]] | ||
| + | [[Category: Inaka, K]] | ||
| + | [[Category: Kamo, M]] | ||
| + | [[Category: Tanaka, H]] | ||
| + | [[Category: Urade, Y]] | ||
| + | [[Category: Prostaglandin d synthase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 19:37, 19 September 2018
Crystal structure of rat hematopoietic prostaglandin D synthase
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