6dnq

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'''Unreleased structure'''
 
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The entry 6dnq is ON HOLD until Paper Publication
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==HBZ77 in complex with KIX and c-Myb==
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<StructureSection load='6dnq' size='340' side='right' caption='[[6dnq]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6dnq]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DNQ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dnq OCA], [http://pdbe.org/6dnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dnq RCSB], [http://www.ebi.ac.uk/pdbsum/6dnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dnq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref> [[http://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE]] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Histone acetyltransferase]]
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[[Category: Stanfield, R L]]
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[[Category: Wright, P E]]
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[[Category: Yang, K]]
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[[Category: Complex]]
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[[Category: Eukaryotic]]
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[[Category: Transcription]]
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[[Category: Transcription coactivator]]
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[[Category: Transcription factor]]
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[[Category: Viral]]

Revision as of 19:50, 19 September 2018

HBZ77 in complex with KIX and c-Myb

6dnq, resolution 2.35Å

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