2vp7

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==DECODING OF METHYLATED HISTONE H3 TAIL BY THE PYGO-BCL9 WNT SIGNALING COMPLEX==
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==Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex==
<StructureSection load='2vp7' size='340' side='right' caption='[[2vp7]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='2vp7' size='340' side='right' caption='[[2vp7]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vpg|2vpg]], [[2vpe|2vpe]], [[2vpb|2vpb]], [[2vpd|2vpd]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vpg|2vpg]], [[2vpe|2vpe]], [[2vpb|2vpb]], [[2vpd|2vpd]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vp7 OCA], [http://pdbe.org/2vp7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vp7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vp7 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vp7 OCA], [http://pdbe.org/2vp7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vp7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vp7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vp7 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.
 
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== Function ==
 
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[[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).<ref>PMID:11955446</ref>
 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vp7_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vp7_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Sanchez-Barrena, M J]]
[[Category: Sanchez-Barrena, M J]]
[[Category: Bcl9 hd1 domain]]
[[Category: Bcl9 hd1 domain]]
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[[Category: Chromosomal rearrangement]]
[[Category: Gene regulation]]
[[Category: Gene regulation]]
[[Category: Histone h3k4me2 tail]]
[[Category: Histone h3k4me2 tail]]
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[[Category: Wnt signaling complex]]
[[Category: Wnt signaling complex]]
[[Category: Wnt signaling pathway]]
[[Category: Wnt signaling pathway]]
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[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]

Revision as of 20:56, 19 September 2018

Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex

2vp7, resolution 1.65Å

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