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Sigma factor

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Line 48: Line 48:
**[[3mzy]] – SF-H – ''Fusobacterium nucleatum''<br />
**[[3mzy]] – SF-H – ''Fusobacterium nucleatum''<br />
**[[1h3l]] – ScSF N terminal – ''Streptomyces coelicolor''<br />
**[[1h3l]] – ScSF N terminal – ''Streptomyces coelicolor''<br />
-
**[[5fgm]] – ScSF SIGR region 4<br />
+
**[[5fgm]] – ScSF-R region 4<br />
-
**[[5mww]] – BsSF SIGA region 1.1 - ''Bacillus subtilis'' - NMR <br />
+
**[[5mww]] – BsSF-A region 1.1 - ''Bacillus subtilis'' - NMR <br />
 +
**[[5xe7]] – MtSF-J – ''Mycobacterium tuberculosis''<br />
*Sigma factor complex with DNA
*Sigma factor complex with DNA
Line 70: Line 71:
**[[1rp3]], [[1sc5]] – AaSF-28 + anti-σ factor FLGM <br />
**[[1rp3]], [[1sc5]] – AaSF-28 + anti-σ factor FLGM <br />
**[[5wuq]] – BsSF SIGW + anti-σ factor RSIW <br />
**[[5wuq]] – BsSF SIGW + anti-σ factor RSIW <br />
-
**[[3hug]] – MtSF + membrane protein – ''Mycobacterium tuberculosis''<br />
+
**[[3hug]] – MtSF-L + membrane protein <br />
**[[4nqw]] – MtSF-K region 4 + anti-σ factor<br />
**[[4nqw]] – MtSF-K region 4 + anti-σ factor<br />
**[[4x8k]] – MtSF-A region 2 + RBPA<br />
**[[4x8k]] – MtSF-A region 2 + RBPA<br />
 +
**[[6fbv]] – MtSF-A + RNAP subunits α,β,β’,ω - SP Cryo EM<br />
 +
**[[6c05]], [[6c06]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA - Cryo EM<br />
**[[3wod]], [[2a6e]], [[2cw0]], [[5tmf]] – TtSF + RNAP subunits α,β,β’,ω - ''Thermus thermophilus'' <br />
**[[3wod]], [[2a6e]], [[2cw0]], [[5tmf]] – TtSF + RNAP subunits α,β,β’,ω - ''Thermus thermophilus'' <br />
**[[4mq9]], [[2a68]], [[2a69]], [[2a6h]], [[3dxj]], [[3eql]] – TtSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
**[[4mq9]], [[2a68]], [[2a69]], [[2a6h]], [[3dxj]], [[3eql]] – TtSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
**[[2be5]] – TtSF + RNAP subunits α,β,β’,ω + inhibitor<br />
**[[2be5]] – TtSF + RNAP subunits α,β,β’,ω + inhibitor<br />
-
**[[5tmc]] – TtSF SIGA + RNAP subunits α,β,β’,ω + protein + G4P<br />
+
**[[5tmc]] – TtSF-A + RNAP subunits α,β,β’,ω + protein + G4P<br />
 +
**[[5xj0]] – TtSF-A + RNAP subunits α,β,β’,ω + GP39 + GP76<br />
 +
**[[5x22]] – TtSF-A + RNAP subunits α,β,β’,ω + GpA + CMPcPP<br />
**[[1l9u]] – TaSF region 1.1-4 + RNAP subunits α,β,β’,ω<br />
**[[1l9u]] – TaSF region 1.1-4 + RNAP subunits α,β,β’,ω<br />
**[[4yg2]], [[5uag]], [[5uaj]], [[5uaq]] – EcSF ProD + RNAP subunits α,β,β’,ω <br />
**[[4yg2]], [[5uag]], [[5uaj]], [[5uaq]] – EcSF ProD + RNAP subunits α,β,β’,ω <br />
Line 82: Line 87:
**[[4mex]], [[4kmu]], [[4kn4]], [[4kn7]], [[5uac]], [[5uah]], [[5ual]], [[4zh3]], [[4zh4]] – EcSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
**[[4mex]], [[4kmu]], [[4kn4]], [[4kn7]], [[5uac]], [[5uah]], [[5ual]], [[4zh3]], [[4zh4]] – EcSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
**[[4xsx]], [[4xsy]], [[4xsz]] – EcSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
**[[4xsx]], [[4xsy]], [[4xsz]] – EcSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
-
**[[4mey]], [[4ljz]], [[4lk1]] – EcSF ProD + RNAP subunits α,β,β’,ω <br />
+
**[[6byu]] – EcSF ProD + RNAP subunits α,β,β’,ω + ppApp <br />
 +
**[[4mey]], [[4ljz]], [[4lk1]], [[6cux]] – EcSF ProD + RNAP subunits α,β,β’,ω <br />
 +
**[[6c9y]], [[6ca0]] – EcSF ProD + RNAP subunits α,β,β’,ω - Cryo EM<br />
**[[5byh]] – EcSF-45 + RNAP subunits α,β,β’,ω <br />
**[[5byh]] – EcSF-45 + RNAP subunits α,β,β’,ω <br />
**[[5nwt]] – EcSF-54 + RNAP subunits α,β,β’,ω <br />
**[[5nwt]] – EcSF-54 + RNAP subunits α,β,β’,ω <br />
Line 91: Line 98:
**[[4cxf]] – SF CNRH + CNRY – ''Cupriavidus metallidurans''<br />
**[[4cxf]] – SF CNRH + CNRY – ''Cupriavidus metallidurans''<br />
**[[4g6d]], [[4g8x]], [[4g94]] – SF ProD region 4 + Orf067 – ''Staphylococcus aureus''<br />
**[[4g6d]], [[4g8x]], [[4g94]] – SF ProD region 4 + Orf067 – ''Staphylococcus aureus''<br />
 +
**[[5yix]] – SF RpoD + GCRA - ''Caulobacter crescentus''<br />
*Sigma factor complex with protein and DNA
*Sigma factor complex with protein and DNA
Line 101: Line 109:
**[[4xlp]], [[4xlq]], [[5tjg]] – TaSF SIGA + RNAP subunits α,β,β’,ω + DNA <br />
**[[4xlp]], [[4xlq]], [[5tjg]] – TaSF SIGA + RNAP subunits α,β,β’,ω + DNA <br />
**[[1l9u]], [[1l9z]] – TaSF + RNAP subunits α,β,β’,ω + DNA – Cryo EM <br />
**[[1l9u]], [[1l9z]] – TaSF + RNAP subunits α,β,β’,ω + DNA – Cryo EM <br />
-
**[[4xlr]], [[4xls]] – TaSF SIGA + RNAP subunits α,β,β’,ω + CarD-like transcriptional regulator + DNA <br />
+
**[[4xlr]], [[4xls]] – TaSF-A + RNAP subunits α,β,β’,ω + CarD-like transcriptional regulator + DNA <br />
**[[3iyd]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + catabolite gene activator + DNA<br />
**[[3iyd]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + catabolite gene activator + DNA<br />
**[[4jk1]], [[4jk2]], [[4jkr]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + G4P<br />
**[[4jk1]], [[4jk2]], [[4jkr]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + G4P<br />
**[[4yln]], [[4ylo]], [[4ylp]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + DNA<br />
**[[4yln]], [[4ylo]], [[4ylp]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + DNA<br />
**[[5nss]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + phage shock protein F + DNA - Cryo EM<br />
**[[5nss]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + phage shock protein F + DNA - Cryo EM<br />
-
**[[5nsr]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + DNA - Cryo EM<br />
+
**[[5nsr]], [[6gh6]], [[6gh5]], [[6gfw]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + DNA - Cryo EM<br />
-
**[[5voi]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA <br />
+
**[[5voi]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA <br />
-
**[[5d4c]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + CTP + ATP<br />
+
**[[6cuu]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + antibiotic<br />
-
**[[5d4d]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + CTP + NAD<br />
+
**[[5d4c]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + CTP + ATP<br />
-
**[[5d4e]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + CTP + dephosphate-CoA<br />
+
**[[5d4d]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + CTP + NAD<br />
-
**[[5uha]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA <br />
+
**[[5d4e]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + CTP + dephosphate-CoA<br />
 +
**[[5uha]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA <br />
 +
**[[6c04]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA + DNA - Cryo EM<br />
**[[5uhe]], [[5uhf]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + inhibitor<br />
**[[5uhe]], [[5uhf]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + inhibitor<br />
-
**[[5uhg]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + antibiotic + inhibitor<br />
+
**[[5uhg]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA + antibiotic + inhibitor<br />
-
**[[5uhb]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + antibiotic<br />
+
**[[5uhb]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA + antibiotic<br />
-
**[[5tw1]] – MsSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + peptide - ''Mycobacterium smegmatis''<br />
+
**[[6bzo]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA + DNA + antibiotic - Cryo EM<br />
-
**[[5vi8]] – MsSF SIGA + MsRNAP subunits α,β,β’,ω + DNA <br />
+
**[[5tw1]], [[6cce]] – MsSF-A + MtRNAP subunits α,β,β’,ω + DNA + peptide - ''Mycobacterium smegmatis''<br />
 +
**[[5vi8]] – MsSF-A + MsRNAP subunits α,β,β’,ω + DNA <br />
 +
**[[6ccv]] – MsSF-A + MtRNAP subunits α,β,β’,ω + DNA + peptide + RbpA <br />
 +
**[[6ccf]] – MsSF-A + MtRNAP subunits α,β,β’,ω + DNA + peptide + antibiotic<br />
*Sigma factor complex with protein, DNA and RNA
*Sigma factor complex with protein, DNA and RNA
-
**[[5vi5]] – MsSF SIGA + MsRNAP subunits α,β,β’,ω + RbpA + DNA + RNA<br />
+
**[[5vi5]] – MsSF-A + MsRNAP subunits α,β,β’,ω + RbpA + DNA + RNA<br />
-
**[[4xln]] – TaSF SIGA + RNAP subunits α,β,β’,ω + DNA + RNA <br />
+
**[[4xln]] – TaSF-A + RNAP subunits α,β,β’,ω + DNA + RNA <br />
**[[5ipl]], [[5ipm]], [[5ipn]] – EcSF RpoS + EcRNAP subunits α,β,β’,ω + DNA + RNA<br />
**[[5ipl]], [[5ipm]], [[5ipn]] – EcSF RpoS + EcRNAP subunits α,β,β’,ω + DNA + RNA<br />
-
**[[5e17]], [[5e18]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + RNA<br />
+
**[[6b6h]] – EcSF RpoD + EcRNAP subunits α,β,β’,ω + DNA + RNA - Cryo EM<br />
-
**[[5x22]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + RNA + CMPPP<br />
+
**[[5e17]], [[5e18]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA<br />
-
**[[5vo8]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + RNA + GTP<br />
+
**[[5x22]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + CMPPP<br />
-
**[[5i2d]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + transcriptional regulator + DNA + RNA<br />
+
**[[5vo8]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + GTP<br />
-
**[[5uh5]], [[5uh8]], [[5uh9]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + RNA<br />
+
**[[5x21]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + antibiotic<br />
-
**[[5uh6]], [[5uhc]], [[5uhd]], [[5x21]] – MtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + RNA + antibiotic<br />
+
**[[5i2d]] – TtSF-A + TtRNAP subunits α,β,β’,ω + transcriptional regulator + DNA + RNA<br />
 +
**[[5uh5]], [[5uh8]], [[5uh9]] – MtSF-A + MtRNAP subunits α,β,β’,ω + DNA + RNA<br />
 +
**[[5uh6]], [[5uhc]], [[5uhd]], [[5x21]] – MtSF-A + TtRNAP subunits α,β,β’,ω + DNA + RNA + antibiotic<br />
}}
}}
== References ==
== References ==

Revision as of 22:51, 19 September 2018

Structure of sigma factor of E.Coli RNAP (grey) in complex with promoter DNA and ethylene glycol (PDB code 4lup).

Drag the structure with the mouse to rotate

3D structures of sigma factor

Updated on 19-September-2018

References

1. Felklistov, Andrey, Brian D. Sharon, Seth A. Darst, and Carol A. Gross. "Bacterial Sigma Factors: A Historical, Structural, and Genomic Perspective." The Annual Review of Microbiology 68 (2014): 357-76.

2. Voet, Donald, Judith G. Voet, and Charlotte W. Pratt. Fundamentals of Biochemistry: Life at the Molecular Level. 3rd ed. Hoboken, NJ: Wiley, 2008.

3. Mooney, R. A., S. A. Darst, and R. Landick. "Sigma and RNA Polymerase: An On-again, Off-again Relationship?" Molecular Cell 20.3 (2005): 335-45.


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Wally Novak, Michal Harel

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