Stathmin
From Proteopedia
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<StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code [[3ryf]])' scene=''> | <StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code [[3ryf]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Stathmin''' (STM) regulates microtubules dynamics. Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton. STM binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly. Phosphorylation of STM weakens the binding of STM to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle. Thus, STM is an oncoprotein. STM contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer<ref>PMID:15216892</ref>. | + | '''Stathmin-4''' (STM-4) regulates microtubules dynamics. Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton. STM-4 binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly. Phosphorylation of STM-4 weakens the binding of STM-4 to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle. Thus, STM-4 is an oncoprotein. STM-4 contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer<ref>PMID:15216892</ref>. |
== Disease == | == Disease == | ||
| - | Decreased levels of STM are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>. | + | Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>. |
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of stathmin == | + | == 3D Structures of stathmin-4 == |
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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**[[4iij]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP <br /> | **[[4iij]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP <br /> | ||
**[[4ihj]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP <br /> | **[[4ihj]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP <br /> | ||
| - | **[[5jqg]], [[4wbn]], [[4i55]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative <br /> | + | **[[5xiw]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + colchicin <br /> |
| + | **[[5xke]] – rSTM-4 + tubulin + protein + GTP + GDP + colchicin derivative<br /> | ||
| + | **[[5xkh]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-cancer drug<br /> | ||
| + | **[[5jqg]], [[4wbn]], [[4i55]], [[5xp3]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative <br /> | ||
| + | **[[5yl2]], [[5ylj]], [[5yls]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6d88]], [[6fkj]], [[6fkl]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + inhibitor <br /> | ||
| + | **[[5xkf]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + inhibitor<br /> | ||
**[[4o2a]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor<br /> | **[[4o2a]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor<br /> | ||
**[[4i50]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + epothilone <br /> | **[[4i50]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + epothilone <br /> | ||
| - | **[[4o4l]], [[5j2t]], [[5bmv]], [[5la6]], [[5jh7]], [[5jvd]], [[5fnv]], [[5c8y]], [[5ca0]], [[5ca1]], [[5cb4]], [[4yj2]], [[4yj3]], [[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[4tuy]], [[4zol]], [[4tv8]], [[4tv9]], [[4o4j]], [[4o4l]], [[5i50]], [[4i4t]], [[4o4i]], [[4o2l]], [[5iyz]], [[5la6]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-cancer drugs<br /> | + | **[[4o4l]], [[5j2t]], [[5bmv]], [[5la6]], [[5jh7]], [[5jvd]], [[5fnv]], [[5c8y]], [[5ca0]], [[5ca1]], [[5cb4]], [[4yj2]], [[4yj3]], [[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[4tuy]], [[4zol]], [[4tv8]], [[4tv9]], [[4o4j]], [[4o4l]], [[5i50]], [[4i4t]], [[4o4i]], [[4o2l]], [[5iyz]], [[5la6]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5yl4]], [[5xkg]], [[5xlt]], [[6fii]], [[6fjf]], [[6fjm]], [[5xlz]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-cancer drugs<br /> |
**[[4o2b]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-gout drug<br /> | **[[4o2b]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-gout drug<br /> | ||
**[[5lov]], [[5njh]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + azoamide<br /> | **[[5lov]], [[5njh]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + azoamide<br /> | ||
Revision as of 20:56, 20 September 2018
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3D Structures of stathmin-4
Updated on 20-September-2018
References
- ↑ Curmi PA, Gavet O, Charbaut E, Ozon S, Lachkar-Colmerauer S, Manceau V, Siavoshian S, Maucuer A, Sobel A. Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin. Cell Struct Funct. 1999 Oct;24(5):345-57. PMID:15216892
- ↑ Cheon MS, Fountoulakis M, Cairns NJ, Dierssen M, Herkner K, Lubec G. Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease. J Neural Transm Suppl. 2001;(61):281-8. PMID:11771751
