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Symporter
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Dipeptide:H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Initial/2'> |
== Function == | == Function == | ||
Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>. | Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>. | ||
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**[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR /> | **[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR /> | ||
| - | *Di-or tripeptide | + | *Di-or tripeptide/H+ symporter |
| - | **[[4ja4]], [[4xni]], [[4xnj]], [[4d2b]], [[4aps]], [[5d6k]], [[5mmt]] – StSymp – ''Streptococcus thermophilus''<BR /> | + | **[[4ja4]], [[4xni]], [[4xnj]], [[4d2b]], [[4aps]], [[5d6k]], [[5mmt]], [[5d6k]], [[5oxo]], [[5oxp]], [[5oxq]], [[6eia]], [[6fmr]], [[6fmy]] – StSymp – ''Streptococcus thermophilus''<BR /> |
| - | **[[4d2d]] – StSymp + tripeptide<BR /> | + | **[[4d2d]], [[6ghj]] – StSymp + tripeptide<BR /> |
| - | **[[4d2c]], [[5d58]], [[5d59]] – StSymp + dipeptide<BR /> | + | **[[4d2c]], [[5d58]], [[5d59]], [[5oxk]], [[5oxl]], [[5oxm]], [[5oxn]] – StSymp + dipeptide<BR /> |
*Oligopeptide/H+ symporter | *Oligopeptide/H+ symporter | ||
**[[4lep]], [[4tph]] – SoSymp – ''Shewanella oneidensis''<BR /> | **[[4lep]], [[4tph]] – SoSymp – ''Shewanella oneidensis''<BR /> | ||
| + | **[[2xut]] – SoSymp (mutant) <BR /> | ||
**[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR /> | **[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR /> | ||
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**[[4n7w]] – YfSymp – ''Yersinia frederiksenii''<BR /> | **[[4n7w]] – YfSymp – ''Yersinia frederiksenii''<BR /> | ||
**[[4n7x]] – YfSymp (mutant) <BR /> | **[[4n7x]] – YfSymp (mutant) <BR /> | ||
| + | **[[3zuy]] – Symp - ''Neisseria meningitidis''<BR /> | ||
| + | **[[3zux]] – Symp (mutant) <BR /> | ||
*L-fucose/H+ symporter | *L-fucose/H+ symporter | ||
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**[[3o7q]] – EcSymp <BR /> | **[[3o7q]] – EcSymp <BR /> | ||
**[[3o7p]] – EcSymp (mutant)<BR /> | **[[3o7p]] – EcSymp (mutant)<BR /> | ||
| + | |||
| + | *Lactose/H+ symporter | ||
| + | |||
| + | **[[1pv6]] – EcSymp (mutant)<BR /> | ||
| + | **[[1pv7]], [[4oaa]] – EcSymp (mutant) + thiodigalactoside<BR /> | ||
*Sodium/glucose symporter | *Sodium/glucose symporter | ||
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**[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR /> | **[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR /> | ||
**[[3dh4]] – VpSymp + galactose <BR /> | **[[3dh4]] – VpSymp + galactose <BR /> | ||
| + | **[[4m64]] – Symp (mutant) - ''Salmonella typhimurium''<BR /> | ||
*Sodium/citrate symporter | *Sodium/citrate symporter | ||
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**[[5a1s]] – Symp + citrate – ''Salmonella enterica''<BR /> | **[[5a1s]] – Symp + citrate – ''Salmonella enterica''<BR /> | ||
**[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate – ''Klebsiella pneumoniae''<BR /> | **[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate – ''Klebsiella pneumoniae''<BR /> | ||
| - | **[[5xar]] – KpSymp <BR /> | + | **[[4bpq]], [[5xar]] – KpSymp <BR /> |
| + | |||
| + | *Sodium/neurotransmitter symporter LeuT | ||
| + | |||
| + | **[[3qs4]], [[3qs5]], [[3qs6]] – AaSymp (mutant) + tryptophan – ''Aquifex aeolicus''<BR /> | ||
| + | **[[3f4i]] – AaSymp + Na <BR /> | ||
| + | **[[3f48]] – AaSymp + alaine + Na<BR /> | ||
| + | **[[3f4j]] – AaSymp + glycine + Na<BR /> | ||
| + | **[[2a65]] – AaSymp + leucine <BR /> | ||
| + | **[[2qb4]] – AaSymp + leucine + desipramine<BR /> | ||
| + | **[[2qei]] – AaSymp + alaine + clomipramine<BR /> | ||
| + | **[[3gwu]] – AaSymp + sertraline + Na<BR /> | ||
| + | **[[3gwv]], [[3gww]] – AaSymp + fluoxetine + Na<BR /> | ||
*Divalent ion/sodium symporter | *Divalent ion/sodium symporter | ||
| - | **[[5ul7]], [[5ul9]], [[5uld]], [[5ule]] – Symp + Na – ''Vibrio cholerae''<BR /> | + | **[[5ul7]], [[5ul9]], [[5uld]], [[5ule]], [[4f35]] – Symp + Na – ''Vibrio cholerae''<BR /> |
*Purine/H+ symporter | *Purine/H+ symporter | ||
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*Glutamate/H+ symporter | *Glutamate/H+ symporter | ||
| - | **[[5dwy]] – TkSymp – ''Thermococcus kodakarensis''<BR /> | + | **[[5dwy]], [[4ky0]] – TkSymp – ''Thermococcus kodakarensis''<BR /> |
**[[5e9s]] – TkSymp + aspartate<BR /> | **[[5e9s]] – TkSymp + aspartate<BR /> | ||
| - | + | **[[4oyf]] – PhSymp - ''Pyrococcus horikishii'' <BR /> | |
| + | **[[2nwl]] – PhSymp (mutant) + aspartate<BR /> | ||
}} | }} | ||
Revision as of 23:03, 21 September 2018
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3D Structures of symporter
Updated on 21-September-2018
References
- ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:http://dx.doi.org/10.1210/er.2001-0029
- ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
- ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:http://dx.doi.org/10.15252/embr.201338403
