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T-cell receptor
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' scene='53/536684/Cv/1' caption='T-cell receptor α chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'> |
== Function == | == Function == | ||
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**[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br /> | **[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br /> | ||
**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br /> | **[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br /> | ||
| - | **[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]] – hTCR α+β chains<br /> | + | **[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]], [[6eh4]], [[6eh5]], [[6eh6]], [[6eh7]], [[6eh8]], [[6eh9]], [[6fr6]], [[6fr7]], [[6fr8]], [[6fr9]], [[6fra]], [[6frb]], [[6frc]], [[6fum]], [[6fun]], [[6fuo]], [[6fup]], [[6fuq]], [[6fur]], [[6at6]], [[6fr3]], [[6fr4]], [[6fr5]] – hTCR α+β chains<br /> |
**[[4ei6]] – h/mTCR α+β chains <br /> | **[[4ei6]] – h/mTCR α+β chains <br /> | ||
**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br /> | **[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br /> | ||
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*TCR complex with MHC and antigen | *TCR complex with MHC and antigen | ||
| - | **[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> | + | **[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]], [[6at5]], [[6avf]], [[6avg]], [[6bj2]], [[6bj3]], [[6bj8]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> |
**[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + antigen <br /> | **[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + antigen <br /> | ||
**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br /> | **[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br /> | ||
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**[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> | **[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> | ||
**[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> | **[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> | ||
| - | **[[5xov]] – hTCR δ+β chains + MHC + β-2 microglobulin + polypeptide <br /> | + | **[[5xov]], [[5xot]] – hTCR δ+β chains + MHC + β-2 microglobulin + polypeptide <br /> |
**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br /> | **[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br /> | ||
**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> | **[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> | ||
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**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br /> | **[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br /> | ||
**[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br /> | **[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br /> | ||
| - | **[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]] – mTCR α+β chains + MHC + polypeptide <br /> | + | **[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]], [[6bga]] – mTCR α+β chains + MHC + polypeptide <br /> |
**[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br /> | **[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br /> | ||
**[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br /> | **[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br /> | ||
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**[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br /> | **[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br /> | ||
**[[5wki]] – hTCR α+β chains + β-2 microglobulin + CD1B <br /> | **[[5wki]] – hTCR α+β chains + β-2 microglobulin + CD1B <br /> | ||
| + | **[[6c09]] – hTCR α+β chains + β-2 microglobulin + CD1C <br /> | ||
**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br /> | **[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br /> | ||
**[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br /> | **[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br /> | ||
Revision as of 19:39, 24 September 2018
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3D structures of T-cell receptor
Updated on 24-September-2018
References
- ↑ Kang L, Sebastian BM, Pritchard MT, Pratt BT, Previs SF, Nagy LE. Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol Clin Exp Res. 2007 Sep;31(9):1581-8. Epub 2007 Jul 11. PMID:17624994 doi:http://dx.doi.org/10.1111/j.1530-0277.2007.00452.x
- ↑ Uttenthal BJ, Chua I, Morris EC, Stauss HJ. Challenges in T cell receptor gene therapy. J Gene Med. 2012 Jun;14(6):386-99. doi: 10.1002/jgm.2637. PMID:22610778 doi:http://dx.doi.org/10.1002/jgm.2637
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
