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Thiolase

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<StructureSection load='4c2j' size='450' side='right' caption='Human 3-ketoacyl-CoA complex with CoA and ethylene glycol(PDB code [[4c2j]]).' scene='44/447919/Cv/7'>
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<StructureSection load='4c2j' size='350' side='right' caption='Human 3-ketoacyl-CoA complex with CoA and ethylene glycol(PDB code [[4c2j]]).' scene='44/447919/Cv/7'>
== Function ==
== Function ==
Two different classes of '''thiolases''' are found.<br />
Two different classes of '''thiolases''' are found.<br />
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**[[4ubv]] – MtKCT + CoA + acetyl CoA <br />
**[[4ubv]] – MtKCT + CoA + acetyl CoA <br />
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*Acetoacetyl-CoA thiolase
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*Acetoacetyl-CoA thiolase or acetyl-CoA acetyltransferase
**[[1m4s]], [[1m4t]], [[1dlu]], [[1qfl]] - ZrACT – ''Zoogloea ramigera''<br />
**[[1m4s]], [[1m4t]], [[1dlu]], [[1qfl]] - ZrACT – ''Zoogloea ramigera''<br />
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**[[5f0v]], [[5f38]], [[4wys]] – ACT – ''Escherichia coli'' <br />
**[[5f0v]], [[5f38]], [[4wys]] – ACT – ''Escherichia coli'' <br />
**[[4o9a]], [[4o99]], [[4o9c]], [[4nzs]] – ReACT <br />
**[[4o9a]], [[4o99]], [[4o9c]], [[4nzs]] – ReACT <br />
 +
**[[5xyj]], [[5xz5]] – yACT <br />
*Acetoacetyl-CoA thiolase complex
*Acetoacetyl-CoA thiolase complex
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**[[1wl4]] – hACT cytosolic + CoA <br />
**[[1wl4]] – hACT cytosolic + CoA <br />
**[[4xl4]] – CaACT + CoA <br />
**[[4xl4]] – CaACT + CoA <br />
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**[[6et9]] – MtACT + PFAM DUF35 + hydroxymethylglutaryl-CoA synthase - ''Methanothermococcus thermolithotrophicus''<br />
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**[[6esq]] – MtACT + CoA + PFAM DUF35 + hydroxymethylglutaryl-CoA synthase <br />
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**[[6are]] – ACT + CoA + acetate - ''Aspergillus fumigatus'' <br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 19:17, 25 September 2018

Human 3-ketoacyl-CoA complex with CoA and ethylene glycol(PDB code 4c2j).

Drag the structure with the mouse to rotate

3D Structures of Thiolase

Updated on 25-September-2018

References

  1. ↑ Sundaramoorthy R, Micossi E, Alphey MS, Germain V, Bryce JH, Smith SM, Leonard GA, Hunter WN. The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation. J Mol Biol. 2006 Jun 2;359(2):347-57. Epub 2006 Mar 29. PMID:16630629 doi:http://dx.doi.org/10.1016/j.jmb.2006.03.032
  2. ↑ Soto G, Stritzler M, Lisi C, Alleva K, Pagano ME, Ardila F, Mozzicafreddo M, Cuccioloni M, Angeletti M, Ayub ND. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. J Exp Bot. 2011 Nov;62(15):5699-711. doi: 10.1093/jxb/err287. Epub 2011 Sep 9. PMID:21908473 doi:http://dx.doi.org/10.1093/jxb/err287
  3. ↑ Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK. The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities. Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3212-25. doi:, 10.1107/S1399004714023827. Epub 2014 Nov 22. PMID:25478839 doi:http://dx.doi.org/10.1107/S1399004714023827

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