5zf8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human dihydroorotate dehydrogenase in complex with 277-11-OAc== | |
| - | + | <StructureSection load='5zf8' size='340' side='right' caption='[[5zf8]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5zf8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZF8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9BO:(2S,3E,7E)-9-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,7-dimethylnona-3,7-dien-2-yl+acetate'>9BO</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zf8 OCA], [http://pdbe.org/5zf8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zf8 RCSB], [http://www.ebi.ac.uk/pdbsum/5zf8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zf8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Amalia, E]] | ||
| + | [[Category: Harada, S]] | ||
| + | [[Category: Inaoka, K D]] | ||
| + | [[Category: Kido, Y]] | ||
| + | [[Category: Kita, K]] | ||
| + | [[Category: Miyazaki, Y]] | ||
| + | [[Category: Moore, L A]] | ||
[[Category: Nakamura, M]] | [[Category: Nakamura, M]] | ||
| + | [[Category: Saimoto, H]] | ||
[[Category: Sakai, C]] | [[Category: Sakai, C]] | ||
| - | [[Category: Inaoka, K.D]] | ||
| - | [[Category: Saimoto, H]] | ||
| - | [[Category: Harada, S]] | ||
[[Category: Shiba, T]] | [[Category: Shiba, T]] | ||
| - | [[Category: | + | [[Category: Dihydroorotate/orotate]] |
| - | [[Category: | + | [[Category: Inhibitor complex]] |
| - | [[Category: | + | [[Category: Mitochondrial inner membrane]] |
| - | [[Category: | + | [[Category: Oxidoreductase]] |
| - | [[Category: | + | [[Category: Rossmann fold]] |
| + | [[Category: Ubiquinone/ubiquinol]] | ||
Revision as of 07:57, 26 September 2018
Structure of human dihydroorotate dehydrogenase in complex with 277-11-OAc
| |||||||||||
