5zyp
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Yeast Ctr9/Paf1 complex== | |
| - | + | <StructureSection load='5zyp' size='340' side='right' caption='[[5zyp]], [[Resolution|resolution]] 2.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5zyp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZYP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zyp OCA], [http://pdbe.org/5zyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zyp RCSB], [http://www.ebi.ac.uk/pdbsum/5zyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zyp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CTR9_YEAST CTR9_YEAST]] The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. In complex with PAF1, required for normal CLN1 and CLN2 G1 cyclin expression in late G1. Also has a role in chromosome segregation where it appears to be involved in microtubule placement.<ref>PMID:10219085</ref> <ref>PMID:15643076</ref> <ref>PMID:16246725</ref> <ref>PMID:8978028</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Long, J]] | [[Category: Long, J]] | ||
| + | [[Category: Xie, Y]] | ||
| + | [[Category: Zheng, M]] | ||
[[Category: Zhou, H]] | [[Category: Zhou, H]] | ||
| - | [[Category: | + | [[Category: Complex]] |
| - | [[Category: | + | [[Category: Tpr]] |
| + | [[Category: Transciption]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 07:58, 26 September 2018
Structure of the Yeast Ctr9/Paf1 complex
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Categories: Long, J | Xie, Y | Zheng, M | Zhou, H | Complex | Tpr | Transciption | Transcription
