6ff3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I== | |
| - | + | <StructureSection load='6ff3' size='340' side='right' caption='[[6ff3]], [[Resolution|resolution]] 2.57Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ff3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FF3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FF3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cbp|4cbp]], [[1gzr|1gzr]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ff3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ff3 OCA], [http://pdbe.org/6ff3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ff3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ff3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ff3 ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IMPL2_DROME IMPL2_DROME]] Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion. [[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brzozowski, A M]] | ||
[[Category: Kristensen, O]] | [[Category: Kristensen, O]] | ||
| - | [[Category: Brzozowski, A.M]] | ||
[[Category: Kulahin, N]] | [[Category: Kulahin, N]] | ||
| + | [[Category: Meyts, P D]] | ||
[[Category: Schluckebier, G]] | [[Category: Schluckebier, G]] | ||
| + | [[Category: Viola, C M]] | ||
| + | [[Category: Drosophila]] | ||
| + | [[Category: Igf-i]] | ||
| + | [[Category: Imaginal morphogenesis]] | ||
| + | [[Category: Insulin binding protein]] | ||
| + | [[Category: Peptide binding protein]] | ||
Revision as of 08:11, 26 September 2018
Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I
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