4n5e

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<StructureSection load='4n5e' size='340' side='right' caption='[[4n5e]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
<StructureSection load='4n5e' size='340' side='right' caption='[[4n5e]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4n5e]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N5E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4n5e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N5E FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tf7|3tf7]], [[3tfk|3tfk]], [[3tjh|3tjh]], [[3tpu|3tpu]], [[4ms8|4ms8]], [[4mxq|4mxq]], [[4mvb|4mvb]], [[4n0c|4n0c]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tf7|3tf7]], [[3tfk|3tfk]], [[3tjh|3tjh]], [[3tpu|3tpu]], [[4ms8|4ms8]], [[4mxq|4mxq]], [[4mvb|4mvb]], [[4n0c|4n0c]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5e OCA], [http://pdbe.org/4n5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n5e RCSB], [http://www.ebi.ac.uk/pdbsum/4n5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5e OCA], [http://pdbe.org/4n5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n5e RCSB], [http://www.ebi.ac.uk/pdbsum/4n5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE]] Involved in the presentation of foreign antigens to the immune system.
[[http://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE]] Involved in the presentation of foreign antigens to the immune system.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The T cell antigen receptor (TCR)-peptide-major histocompatibility complex (MHC) interface is composed of conserved and diverse regions, yet the relative contribution of each in shaping recognition by T cells remains unclear. Here we isolated cross-reactive peptides with limited homology, which allowed us to compare the structural properties of nine peptides for a single TCR-MHC pair. The TCR's cross-reactivity was rooted in highly similar recognition of an apical 'hot-spot' position in the peptide with tolerance of sequence variation at ancillary positions. Furthermore, we found a striking structural convergence onto a germline-mediated interaction between the TCR CDR1alpha region and the MHC alpha2 helix in twelve TCR-peptide-MHC complexes. Our studies suggest that TCR-MHC germline-mediated constraints, together with a focus on a small peptide hot spot, might place limits on peptide antigen cross-reactivity.
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Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.,Adams JJ, Narayanan S, Birnbaum ME, Sidhu SS, Blevins SJ, Gee MH, Sibener LV, Baker BM, Kranz DM, Garcia KC Nat Immunol. 2016 Jan;17(1):87-94. doi: 10.1038/ni.3310. Epub 2015 Nov 2. PMID:26523866<ref>PMID:26523866</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4n5e" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Lk3 transgenic mice]]
[[Category: Adams, J J]]
[[Category: Adams, J J]]
[[Category: Birnbaum, M E]]
[[Category: Birnbaum, M E]]

Revision as of 08:32, 26 September 2018

42F3 TCR pCPA12/H-2Ld complex

4n5e, resolution 3.06Å

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