2wmn

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==STRUCTURE OF THE COMPLEX BETWEEN DOCK9 AND CDC42-GDP.==
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==Structure of the complex between DOCK9 and Cdc42-GDP.==
<StructureSection load='2wmn' size='340' side='right' caption='[[2wmn]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
<StructureSection load='2wmn' size='340' side='right' caption='[[2wmn]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
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[[http://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wmn_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wmn_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Dedicator of cytokinesis protein|Dedicator of cytokinesis protein]]
*[[GTP-binding protein|GTP-binding protein]]
*[[GTP-binding protein|GTP-binding protein]]
== References ==
== References ==
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[[Category: Roe, S M]]
[[Category: Roe, S M]]
[[Category: Yang, J]]
[[Category: Yang, J]]
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[[Category: Alternative splicing]]
[[Category: Cdc42]]
[[Category: Cdc42]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]
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[[Category: Coiled coil]]
[[Category: Dock9]]
[[Category: Dock9]]
[[Category: Gef]]
[[Category: Gef]]
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
[[Category: Prenylation]]
[[Category: Prenylation]]

Revision as of 09:46, 26 September 2018

Structure of the complex between DOCK9 and Cdc42-GDP.

2wmn, resolution 2.39Å

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Proteopedia Page Contributors and Editors (what is this?)

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