Trypanothione reductase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene='48/489332/Cv/1' pspeed='8'> |
== Function == | == Function == | ||
| - | '''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. | + | '''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor<ref>PMID:1957352</ref>. |
== Relevance == | == Relevance == | ||
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**[[1gxf]] - TcTTR + inhibitor<br /> | **[[1gxf]] - TcTTR + inhibitor<br /> | ||
**[[2wba]], [[2wov]] - TbTTR + NADPH <br /> | **[[2wba]], [[2wov]] - TbTTR + NADPH <br /> | ||
| - | **[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]], [[4new]] - TbTTR + inhibitor<br /> | + | **[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]], [[4new]], [[6btl]], [[6bu7]] - TbTTR + inhibitor<br /> |
*Trypanothione reductase ternary complex | *Trypanothione reductase ternary complex | ||
Revision as of 21:10, 27 September 2018
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3D structures of trypanothione reductase
Updated on 27-September-2018
References
- ↑ Walsh C, Bradley M, Nadeau K. Molecular studies on trypanothione reductase, a target for antiparasitic drugs. Trends Biochem Sci. 1991 Aug;16(8):305-9. PMID:1957352
- ↑ Rivarola HW, Paglini-Oliva PA. Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution. Curr Drug Targets Cardiovasc Haematol Disord. 2002 Jun;2(1):43-52. PMID:12769656
- ↑ Baiocco P, Poce G, Alfonso S, Cocozza M, Porretta GC, Colotti G, Biava M, Moraca F, Botta M, Yardley V, Fiorillo A, Lantella A, Malatesta F, Ilari A. Inhibition of Leishmania infantum Trypanothione Reductase by Azole-Based Compounds: a Comparative Analysis with Its Physiological Substrate by X-ray Crystallography. ChemMedChem. 2013 Jun 3. doi: 10.1002/cmdc.201300176. PMID:23733388 doi:10.1002/cmdc.201300176
