Tubulin
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]]' scene='43/430888/Cv/2' pspeed='8'> |
== Function == | == Function == | ||
| - | [[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. See also [[Beta tubulin]]. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules<ref>PMID:11297925</ref>. Human TUB contains several numbered subtypes. '''FtsZ''' (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB<ref>PMID:26463348</ref>. See | + | [[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. See also [[Beta tubulin]]. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules<ref>PMID:11297925</ref>. Human TUB contains several numbered subtypes. '''FtsZ''' (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB<ref>PMID:26463348</ref>. See [[Cell division protein]] and [[Beta tubulin]]. |
== Relevance == | == Relevance == | ||
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**[[3rip]] – hTUBG4<br /> | **[[3rip]] – hTUBG4<br /> | ||
| - | * FtsZ | ||
| - | |||
| - | **[[2vxy]], [[2vam]] – BsFtsZ - ''Bacillus subtilis''<br /> | ||
| - | **[[2ve8]] – PaFtsZ gamma domain – ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[2r6r]]– AaFtsZ - ''Aquifex aeolicus''<br /> | ||
| - | **[[1w59]], [[1fsz]] – MjFtsZ - ''Methancaldococcus jannaschii''<br /> | ||
| - | **[[1w5e]], [[1w5f]] – MjFtsZ (mutant) <br /> | ||
| - | **[[3v3t]] – FtsZ (mutant) – ''Clostridium botulinum''<br /> | ||
| - | **[[3zid]] – FtsZ – ''Methanosaeta thermophila''<br /> | ||
| - | **[[3vo9]], [[3vpa]] - SaFtsZ – ''Staphylococcus aureus''<br /> | ||
| - | **[[3wgj]], [[3wgk]] – SaFtsZ (mutant) <br /> | ||
| - | |||
| - | *FtsZ complexes | ||
| - | |||
| - | **[[2rhh]], [[2rhj]] – BsFtsZ+SO4 <br /> | ||
| - | **[[2rhl]] - BsFtsZ+GDP<br /> | ||
| - | **[[2rho]] - BsFtsZ+GDP+GTP-gamma-S<br /> | ||
| - | **[[4u39]] – BsFtsZ + cell division factor<br /> | ||
| - | **[[2ve9]] - PaFtsZ gamma domain+DNA<br /> | ||
| - | **[[2vaw]] – PaFtsZ+GDP<br /> | ||
| - | **[[1ofu]] - PaFtsZ+SULA<br /> | ||
| - | **[[2r75]] - AaFtsZ+8-morpholino-GTP <br /> | ||
| - | **[[2q1x]], [[1rq2]] - MtFtsZ+citrate – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[2q1y]], [[1rlu]] - MtFtsZ+GTP-gamma-S<br /> | ||
| - | **[[1rq7]], [[4kwe]], [[5v68]] - MtFtsZ+GDP<br /> | ||
| - | **[[2vap]] – MjFtsZ+GDP <br /> | ||
| - | **[[1w58]] - MjFtsZ+GMPCPP<br /> | ||
| - | **[[1w5a]] - MjFtsZ+MgGTP<br /> | ||
| - | **[[1w5b]] - MjFtsZ+GTP<br /> | ||
| - | **[[4b45]] – HvFtsZ + GTP-γS – ''Haloferax volcanii''<br /> | ||
| - | **[[3vo8]], [[3voa]], [[5h5g]] - SaFtsZ + GDP <br /> | ||
| - | **[[3wgl]], [[5xdw]], [[5h5h]], [[5h5i]], [[5mn4]], [[5mn6]] – SaFtsZ (mutant) + GDP<br /> | ||
| - | **[[3wgn]] – SaFtsZ + GTP-γS<br /> | ||
| - | **[[3wgm]], [[5mn5]], [[5mn7]], [[5mn8]] – SaFtsZ (mutant) + GTP<br /> | ||
| - | **[[3vob]], [[5xdt]], [[5xdu]] - SaFtsZ + GDP + inhibitor<br /> | ||
| - | **[[5xdv]] - SaFtsZ (mutant) + GDP + inhibitor<br /> | ||
| - | **[[4dxd]] - SaFtsZ + antibiotic <br /> | ||
| - | **[[4b46]] - HvFtsZ + GDP <br /> | ||
| - | **[[4m8i]] - SeFtsZ + GDP – ''Staphylococcus epidermitis''<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 17:15, 28 September 2018
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3D Structures of Tubulin
Updated on 28-September-2018
References
- ↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
- ↑ Arjes HA, Lai B, Emelue E, Steinbach A, Levin PA. Mutations in the bacterial cell division protein FtsZ highlight the role of GTP binding and longitudinal subunit interactions in assembly and function. BMC Microbiol. 2015 Oct 13;15:209. doi: 10.1186/s12866-015-0544-z. PMID:26463348 doi:http://dx.doi.org/10.1186/s12866-015-0544-z
- ↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
- ↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380
