Tubulin
From Proteopedia
(Difference between revisions)
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**[[1jff]] - bTUBA+bTUBB - bovine<br /> | **[[1jff]] - bTUBA+bTUBB - bovine<br /> | ||
**[[3j6f]] - pTUBA+pTUBB – pig - Cryo EM <br /> | **[[3j6f]] - pTUBA+pTUBB – pig - Cryo EM <br /> | ||
| - | **[[3j6e]] - pTUBA+pTUBB +GMPCPP – Cryo EM <br /> | + | **[[3j6e]], [[6evw]] - pTUBA+pTUBB +GMPCPP – Cryo EM <br /> |
| - | **[[3j7i]] - pTUBA+pTUBB +GTP – Cryo EM<br /> | + | **[[6dpu]] - pTUBA+pTUBB +GMPCPP + GTP – Cryo EM <br /> |
| + | **[[3j7i]] - pTUBA+pTUBB + GTP – Cryo EM<br /> | ||
| + | **[[6evx]], [[6evy]], [[6evz]], [[6ew0]], [[6dpv]], [[6dpw]] - pTUBA+pTUBB + GTP + GDP - Cryo EM<br /> | ||
**[[1tub]] - pTUBA+pTUBB – electron diffraction<br /> | **[[1tub]] - pTUBA+pTUBB – electron diffraction<br /> | ||
**[[2btq]] – PdTUBA+PdTUBB<br /> | **[[2btq]] – PdTUBA+PdTUBB<br /> | ||
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**[[5ubq]], [[5ucy]] - TUBA+ TUBB – ''Tetrahymena thermophila'' - Cryo EM <br /> | **[[5ubq]], [[5ucy]] - TUBA+ TUBB – ''Tetrahymena thermophila'' - Cryo EM <br /> | ||
| - | *α-tubulin + β-tubulin complexes with stathmin | + | *α-tubulin + β-tubulin complexes with stathmin-4 |
**[[3hkb]], [[3hkc]], [[3hkd]], [[3hke]], [[3n2g]], [[3n2k]], [[3ryc]], [[3ryf]], [[3ryh]], [[3ryi]], [[4eb6]] – sTUBA+sTUBB+stathmin-4 – sheep<br /> | **[[3hkb]], [[3hkc]], [[3hkd]], [[3hke]], [[3n2g]], [[3n2k]], [[3ryc]], [[3ryf]], [[3ryh]], [[3ryi]], [[4eb6]] – sTUBA+sTUBB+stathmin-4 – sheep<br /> | ||
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**[[3ut5]] - sTUBA+sTUBB+stathmin-4 + vinca peptide<br /> | **[[3ut5]] - sTUBA+sTUBB+stathmin-4 + vinca peptide<br /> | ||
**[[4eb6]] - sTUBA+sTUBB+stathmin-4<br /> | **[[4eb6]] - sTUBA+sTUBB+stathmin-4<br /> | ||
| - | **[[4x1i]], [[4x1k]], [[4x1y]], [[4x20]] - sTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + dolastatin + colchicine<br /> | ||
| - | **[[5kx5]] - sTUBA+sTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ADP + inhibitor<br /> | ||
| - | **[[5eyp]] - sTUBA+sTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + colchicine<br /> | ||
**[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br /> | **[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br /> | ||
**[[5lp6]] – bTUBA1B +bTUBB2B +stathmin-4 + protein<br /> | **[[5lp6]] – bTUBA1B +bTUBB2B +stathmin-4 + protein<br /> | ||
| - | + | **[[5la6]], [[5m7e]], [[5bmv]], [[5lov]], [[5lxt]], [[5lxj]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5mf4]], [[5ov7]], [[5lxs]], [[5xlt]], [[5o7a]], [[5xlt]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + inhibitor<br /> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | **[[5la6]], [[5m7e]], [[5bmv]], [[5lov]], [[5lxt]], [[5lxj]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5mf4]], [[5ov7]], [[5lxs]], [[5xlt]], [[5o7a]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + inhibitor<br /> | + | |
**[[5njh]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + triazolopyrimidine<br /> | **[[5njh]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + triazolopyrimidine<br /> | ||
| - | **[[5iyz]], [[5j2t]], [[5j2u]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]] – bTUBAB1 +bTUBBB2 +stathmin-4 + | + | |
| - | **[[4o2b]] - bTUBA+bTUBB+stathmin-4 + | + | *α-tubulin + β-tubulin complexes with stathmin-4 and tubulin-tyrosine ligase (TTL) |
| - | **[[4tuy]], [[4o4h]], [[4o4i]], [[4o4j]], [[4o4l]], [[4i50]], [[4i4t]], [[4tv8]], [[4zhq]], [[4zi7]], [[4zol]] – pTUBAB1 +pTUBBB2 +stathmin-4 + | + | |
| - | **[[ | + | **[[3du7]], [[3e22]], [[1z2b]], [[1sa0]], [[1sa1]], [[1ffx]] – bTUBA1C+bTUBB2B+stathmin-4<br /> |
| + | **[[4o2a]], [[4iij]], [[4i55]] - bTUBA+bTUBB+stathmin-4 + TTL<br /> | ||
| + | **[[4ihj]] - bTUBA+bTUBB+stathmin-4 + TTL + ADP<br /> | ||
| + | **[[4wbn]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ATP derivative<br /> | ||
| + | **[[5jh7]], [[5xaf]], [[5xag]], [[5xlz]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ATP derivative + drug<br /> | ||
| + | **[[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[5eyp]] - sTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + drug<br /> | ||
| + | **[[5kx5]] - sTUBA+sTUBB+stathmin-4 + TTL + GDP + GTP + ADP + inhibitor<br /> | ||
| + | **[[5iyz]], [[5j2t]], [[5j2u]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]] – bTUBAB1 +bTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + auristatin anti-mitotics<br /> | ||
| + | **[[4o2b]] - bTUBA+bTUBB+stathmin-4 + TTL + drug<br /> | ||
| + | **[[5xp3]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative <br /> | ||
| + | **[[4tuy]], [[4o4h]], [[4o4i]], [[4o4j]], [[4o4l]], [[4i50]], [[4i4t]], [[4tv8]], [[4zhq]], [[4zi7]], [[4zol]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + fungicide<br /> | ||
| + | **[[6d88]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[5yl2]], [[5ylj]], [[5yls]], [[5xhc]], [[5xi5]], [[5xi7]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + inhibitor<br /> | ||
| + | **[[5xiw]], [[5xke]], [[5xkf]], [[5xkg]], [[5xkh]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + drug<br /> | ||
| + | **[[5yl4]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + drug<br /> | ||
*α-tubulin + β-tubulin complex with kinesin | *α-tubulin + β-tubulin complex with kinesin | ||
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**[[3j2u]] - bTUBA+bTUBB+kinesin-like KLP10A head domain<br /> | **[[3j2u]] - bTUBA+bTUBB+kinesin-like KLP10A head domain<br /> | ||
**[[2p4n]] - hTUBA+hTUBB+kinesin heavy chain<br /> | **[[2p4n]] - hTUBA+hTUBB+kinesin heavy chain<br /> | ||
| - | **[[2hxf]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP <br /> | + | **[[2hxf]], [[6b0c]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP - Cryo EM<br /> |
**[[3j6h]] - pTUBA+pTUBB +GMPCPP + kinesin heavy chain – Cryo EM <br /> | **[[3j6h]] - pTUBA+pTUBB +GMPCPP + kinesin heavy chain – Cryo EM <br /> | ||
**[[3j8x]] - pTUBA+pTUBB +GDP + GTP + kinesin heavy chain – Cryo EM <br /> | **[[3j8x]] - pTUBA+pTUBB +GDP + GTP + kinesin heavy chain – Cryo EM <br /> | ||
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**[[2hxh]] - pTUBA+pTUBB+kinesin-like KIF1A+ADP<br /> | **[[2hxh]] - pTUBA+pTUBB+kinesin-like KIF1A+ADP<br /> | ||
**[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br /> | **[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br /> | ||
| + | **[[6boi]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + taxol – Cryo EM<br /> | ||
| + | **[[6b0l]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + AMPPNP + taxol – Cryo EM<br /> | ||
**[[4aqv]], [[4aqw ]]- bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM<br /> | **[[4aqv]], [[4aqw ]]- bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM<br /> | ||
**[[5nd3]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP – Cryo EM<br /> | **[[5nd3]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP – Cryo EM<br /> | ||
**[[5nd2]], [[5nd4]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP + ADP – Cryo EM<br /> | **[[5nd2]], [[5nd4]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP + ADP – Cryo EM<br /> | ||
**[[5nd7]] - bTUBA+bTUBB+kinesin-like KIF20A + AMPPNP – Cryo EM<br /> | **[[5nd7]] - bTUBA+bTUBB+kinesin-like KIF20A + AMPPNP – Cryo EM<br /> | ||
| + | **[[6bbn]] - bTUBA+bTUBB+kinesin-like KIF2A + DARPIN + AMPPNP + GDP + GTP<br /> | ||
**[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br /> | **[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br /> | ||
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] - bTUBA1D+bTUBB2B+kinesin-5 motor domain + AMPPNP – Cryo EM<br /> | **[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] - bTUBA1D+bTUBB2B+kinesin-5 motor domain + AMPPNP – Cryo EM<br /> | ||
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**[[3j6p]] - pTUBA+pTUBB +GTP + GDP + taxol + dynein heavy chain – Cryo EM<br /> | **[[3j6p]] - pTUBA+pTUBB +GTP + GDP + taxol + dynein heavy chain – Cryo EM<br /> | ||
**[[3j6g]] - pTUBA+pTUBB +GTP + GDP + taxol – Cryo EM <br /> | **[[3j6g]] - pTUBA+pTUBB +GTP + GDP + taxol – Cryo EM <br /> | ||
| + | **[[6cvj]], [[6cvn]] - pTUBA+pTUBB + GTP + GDP + tau protein – Cryo EM <br /> | ||
**[[5kmg]] - pTUBA+pTUBB + protein regulator + GTP + GDP – Cryo EM <br /> | **[[5kmg]] - pTUBA+pTUBB + protein regulator + GTP + GDP – Cryo EM <br /> | ||
| + | **[[6bjc]] - pTUBA+pTUBB + targeting protein for Xklp2 + GTP + GMPCPP – Cryo EM <br /> | ||
**[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br /> | **[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br /> | ||
**[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br /> | **[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br /> | ||
Revision as of 18:52, 28 September 2018
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3D Structures of Tubulin
Updated on 28-September-2018
References
- ↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
- ↑ Arjes HA, Lai B, Emelue E, Steinbach A, Levin PA. Mutations in the bacterial cell division protein FtsZ highlight the role of GTP binding and longitudinal subunit interactions in assembly and function. BMC Microbiol. 2015 Oct 13;15:209. doi: 10.1186/s12866-015-0544-z. PMID:26463348 doi:http://dx.doi.org/10.1186/s12866-015-0544-z
- ↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
- ↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380
