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Tumor necrosis factor
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'> |
== Function == | == Function == | ||
'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | ||
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**[[2vfj]] – hTNF ovarian tumor domain <BR /> | **[[2vfj]] – hTNF ovarian tumor domain <BR /> | ||
| - | **[[5m2i]], [[5m2j]], [[5m2m]], [[5wux]] – hTNF + antibody <BR /> | + | **[[5m2i]], [[5m2j]], [[5m2m]], [[5wux]], [[5yoy]] – hTNF + antibody <BR /> |
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 20:23, 28 September 2018
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3D Structures of tumor necrosis factor
Updated on 28-September-2018
References
- ↑ Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2001 Sep;11(9):372-7. PMID:11514191
- ↑ Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009 May;9(5):361-71. doi: 10.1038/nrc2628. Epub 2009 Apr 3. PMID:19343034 doi:http://dx.doi.org/10.1038/nrc2628
