Tyrosine phosphatase
From Proteopedia
(Difference between revisions)
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**[[3rgo]] – mPTP-1<br /> | **[[3rgo]] – mPTP-1<br /> | ||
**[[2yz1]] – mPTP SHPS-1 catalytic domain<br /> | **[[2yz1]] – mPTP SHPS-1 catalytic domain<br /> | ||
| - | **[[1gwz]], [[2b3o]] – hPTP SHP-1 catalytic domain<br /> | ||
| - | **[[1x6c]] - hPTP SHP-1 SH2 domain – NMR<BR /> | ||
| - | **[[2shp]] - hPTP SHP-2 (mutant)<br /> | ||
**[[5k9v]] – hPTPN1<br /> | **[[5k9v]] – hPTPN1<br /> | ||
**[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 (mutant)<br /> | **[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 (mutant)<br /> | ||
| + | **[[6b8e]], [[6b8t]], [[6b8x]], [[6b90]] – hPTPN1B catalytic domain<br /> | ||
| + | **[[6bai]] – hPTPN1B catalytic domain (mutant)<br /> | ||
**[[2b49]] – hPTPN3 catalytic domain<br /> | **[[2b49]] – hPTPN3 catalytic domain<br /> | ||
**[[4qun]] – hPTPN3 catalytic domain (mutant) <br /> | **[[4qun]] – hPTPN3 catalytic domain (mutant) <br /> | ||
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**[[2bij]] – hPTPN5 catalytic domain<br /> | **[[2bij]] – hPTPN5 catalytic domain<br /> | ||
**[[2bv5]] - hPTPN5 catalytic domain (mutant) <br /> | **[[2bv5]] - hPTPN5 catalytic domain (mutant) <br /> | ||
| - | **[[ | + | **[[4hjp]], [[1gwz]], [[2b3o]] – hPTPN6 catalytic domain <br /> |
| - | + | **[[4gry]], [[4grz]], [[4hjq]], [[3ps5]] – hPTPN6 catalytic domain (mutant)<br /> | |
| - | **[[4gry]], [[4grz]], [[4hjq]] – hPTPN6 catalytic domain (mutant)<br /> | + | |
**[[2dn7]] - hPTPN6 FN3 #6 domain - NMR<br /> | **[[2dn7]] - hPTPN6 FN3 #6 domain - NMR<br /> | ||
**[[2dju]], [[2edy]] - hPTPN6 FN3 domain - NMR<br /> | **[[2dju]], [[2edy]] - hPTPN6 FN3 domain - NMR<br /> | ||
| + | **[[1x6c]] - hPTP hPTPN6 SH2 domain – NMR<BR /> | ||
**[[2a3k]], [[1zc0]] – hPTPN7 catalytic domain<br /> | **[[2a3k]], [[1zc0]] – hPTPN7 catalytic domain<br /> | ||
**[[2gp0]], [[2hvl]], [[2qdc]], [[2qdm]], [[2qdp]], [[2qds]], [[2qdt]], [[2qdu]], [[3o4s]], [[3o4t]], [[3o4u]] – hPTPN7 catalytic domain (mutant) <br /> | **[[2gp0]], [[2hvl]], [[2qdc]], [[2qdm]], [[2qdp]], [[2qds]], [[2qdt]], [[2qdu]], [[3o4s]], [[3o4t]], [[3o4u]] – hPTPN7 catalytic domain (mutant) <br /> | ||
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**[[4dgp]] - hPTPN11 SH2+catalytic domains<br /> | **[[4dgp]] - hPTPN11 SH2+catalytic domains<br /> | ||
**[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]], [[4ohl]] - hPTPN11 SH2+catalytic domains (mutant)<br /> | **[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]], [[4ohl]] - hPTPN11 SH2+catalytic domains (mutant)<br /> | ||
| - | **[[5j8r]], [[5i6v]], [[5ibm]], [[5ibs]] - hPTPN11 catalytic domain (mutant)<br /> | + | **[[5j8r]], [[5i6v]], [[5ibm]], [[5ibs]], [[6atd]], [[2shp]] - hPTPN11 catalytic domain (mutant)<br /> |
**[[5hde]] - hPTPN12 catalytic domain <br /> | **[[5hde]] - hPTPN12 catalytic domain <br /> | ||
**[[5glj]] - hPTPN13 PDZ1 domain <br /> | **[[5glj]] - hPTPN13 PDZ1 domain <br /> | ||
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**[[3i36]] – rPTP-η catalytic domain<br /> | **[[3i36]] – rPTP-η catalytic domain<br /> | ||
**[[1c0e]] – bPTP (mutant) – bovine<br /> | **[[1c0e]] – bPTP (mutant) – bovine<br /> | ||
| - | **[[1d1p]], [[2j16]] – yPTP - yeast<br /> | + | **[[1d1p]], [[2j16]], [[6byf]] – yPTP - yeast<br /> |
**[[2j17]] - yPTP (mutant)<br /> | **[[2j17]] - yPTP (mutant)<br /> | ||
**[[5xw4]] – yPTPN CDC14 <br /> | **[[5xw4]] – yPTPN CDC14 <br /> | ||
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**[[3js5]], [[3jvi]] – EhPTP – ''Entamoeba histolytica''<br /> | **[[3js5]], [[3jvi]] – EhPTP – ''Entamoeba histolytica''<br /> | ||
**[[2wjd]], [[2wje]], [[2wjf]] – PTP – ''Streptococcus pneumonia''<br /> | **[[2wjd]], [[2wje]], [[2wjf]] – PTP – ''Streptococcus pneumonia''<br /> | ||
| + | **[[5z59]], [[5z5a]] – TkPTP – ''Thermococcus kodakarensis'' <br /> | ||
| + | **[[5z5b]] - TkPTP (mutant)<br /> | ||
**[[3qy6]], [[3qy7]], [[3qy8]] – BsPTP – ''Bacillus subtilis'' | **[[3qy6]], [[3qy7]], [[3qy8]] – BsPTP – ''Bacillus subtilis'' | ||
*Non-receptor type PTP complex with peptide | *Non-receptor type PTP complex with peptide | ||
| - | **[[1ptt]], [[1ptu]], [[1g1f]], [[1g1g]], [[1g1h]], [[1een]], [[1eeo ]] - hPTP-b catalytic domain (mutant) + peptide<br /> | ||
| - | **[[3i7z]] - hPTP-b catalytic domain + peptide<br /> | ||
**[[3zmp]], [[3zmq]], [[4zrt]] – hPTPN1 catalytic domain + peptide<br /> | **[[3zmp]], [[3zmq]], [[4zrt]] – hPTPN1 catalytic domain + peptide<br /> | ||
| + | **[[3i7z]] - hPTP1B catalytic domain + peptide<br /> | ||
| + | **[[1ptt]], [[1ptu]], [[1g1f]], [[1g1g]], [[1g1h]], [[1een]], [[1eeo ]] - hPTP1B catalytic domain (mutant) + peptide<br /> | ||
| + | **[[1bzh]] - hPTP1B catalytic domain + fluoromalonyl tyrosine peptide<br /> | ||
| + | **[[1bzj]] - hPTP1B catalytic domain + phosphotyrosine mimetic<br /> | ||
**[[4qum]], [[4rh5]], [[4rh9]], [[4rhg]], [[4s0g]] – hPTPN3 catalytic domain (mutant) + peptide<br /> | **[[4qum]], [[4rh5]], [[4rh9]], [[4rhg]], [[4s0g]] – hPTPN3 catalytic domain (mutant) + peptide<br /> | ||
| - | **[[1bzh]] - hPTP 1B catalytic domain + fluoromalonyl tyrosine peptide<br /> | ||
| - | **[[1bzj]] - hPTP 1B catalytic domain + phosphotyrosine mimetic<br /> | ||
**[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br /> | **[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br /> | ||
**[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR /> | **[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR /> | ||
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*Non-receptor type PTP complex with small molecule | *Non-receptor type PTP complex with small molecule | ||
| - | **[[1ptv]], [[1pty]] - | + | **[[1ptv]], [[1pty]] - hPTP1B catalytic domain (mutant) + phosphotyrosine<br /> |
| - | **[[1aax]] - | + | **[[1aax]] - hPTP1B catalytic domain (mutant) + bis-phosphophenyl methane<br /> |
| - | **[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]], [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]], [[4y14]] - | + | **[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]], [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]], [[4y14]], [[6bmr]], [[6bmv]], [[6bmx]], [[6bmu]], [[6bmw]], [[6bmy]], [[5t19]], [[5k9w]], [[6b8z]] - hPTP1B catalytic domain + inhibitor<br /> |
| - | **[[1nwl]], [[1nwe]], [[2fjm]] | + | **[[5kad]], [[5kac]], [[5kab]], [[5ka9]], [[5ka7]], [[5ka3]], [[6b95]], [[1nwl]], [[1nwe]], [[2fjm]], [[6bn5]] – hPTPN1B (mutant) + inhibitor<br /> |
**[[4bjo]] – hPTP1 catalytic domain + NO3<br /> | **[[4bjo]] – hPTP1 catalytic domain + NO3<br /> | ||
| - | **[[5t19]], [[5k9w]] – hPTPN1b + inhibitor<br /> | ||
| - | **[[5kad]], [[5kac]], [[5kab]], [[5ka9]], [[5ka7]], [[5ka3]] – hPTPN1b (mutant) + inhibitor<br /> | ||
**[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br /> | **[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br /> | ||
| - | **[[ | + | **[[6h8r]] – hPTPN5 + inhibitor<br /> |
**[[2cjz]] - hPTPN5 catalytic domain (mutant) + phosphotyrosine<br /> | **[[2cjz]] - hPTPN5 catalytic domain (mutant) + phosphotyrosine<br /> | ||
**[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br /> | **[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br /> | ||
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**[[2i6m]] – SsPTP + WO4<BR /> | **[[2i6m]] – SsPTP + WO4<BR /> | ||
**[[3ido]] – EhPTP + HEPES<br /> | **[[3ido]] – EhPTP + HEPES<br /> | ||
| + | **[[3rgq]] – mPTP-1 + Pi(5)P<br /> | ||
| + | **[[6h8s]] – mPTPN5 + inhibitor<br /> | ||
*Non-receptor type PTP complex with protein | *Non-receptor type PTP complex with protein | ||
| - | **[[2b4s]] - | + | **[[2b4s]] - hPTP1B catalytic domain + insulin receptor<br /> |
**[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br /> | **[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br /> | ||
**[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br /> | **[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br /> | ||
Revision as of 20:29, 1 October 2018
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3D Structures of tyrosine phosphatase
Updated on 01-October-2018
References
- ↑ Paul S, Lombroso PJ. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci. 2003 Nov;60(11):2465-82. PMID:14625689 doi:http://dx.doi.org/10.1007/s00018-003-3123-7
- ↑ Caselli A, Paoli P, Santi A, Mugnaioni C, Toti A, Camici G, Cirri P. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme. Biochim Biophys Acta. 2016 Oct;1864(10):1339-55. doi:, 10.1016/j.bbapap.2016.07.001. Epub 2016 Jul 13. PMID:27421795 doi:http://dx.doi.org/10.1016/j.bbapap.2016.07.001
- ↑ Ostman A, Hellberg C, Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat Rev Cancer. 2006 Apr;6(4):307-20. PMID:16557282 doi:http://dx.doi.org/10.1038/nrc1837
