Tyrosine phosphatase

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Line 15: Line 15:
*'''Non-receptor type tyrosine phosphatase'''
*'''Non-receptor type tyrosine phosphatase'''
-
**[[1a5y]], [[2hnp]], [[2hnq]], [[1oem]], [[1oeo]], [[1oes]], [[1oet]], [[1oeu]], [[1oev]], [[1sug]], [[2cm2]], [[2cm3]], [[3eu0]], [[3i80]], [[3a5j]], [[1bzc]] - hPTP-b catalytic domain – human<br />
+
**[[5k9v]] – hPTPN1 - human<br />
-
**[[1gfy]], [[1i57]], [[1pa1]], [[2f6f]], [[3a5k]], [[3zv2]], [[3qkp]], [[3qkq]] - hPTP-b catalytic domain (mutant) <br />
+
-
**[[1wch]] – hPTP-e<br />
+
-
**[[3pdz]] - hPTP-e PDZ2 domain – NMR<BR />
+
-
**[[1gm1]] - mPTP-BL PDZ2 domain – mouse – NMR<BR />
+
-
**[[1ozi]] - mPTP-BL PDZ2 domain (mutant) – NMR<BR />
+
-
**[[3rgo]] – mPTP-1<br />
+
-
**[[2yz1]] – mPTP SHPS-1 catalytic domain<br />
+
-
**[[5k9v]] – hPTPN1<br />
+
**[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 (mutant)<br />
**[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 (mutant)<br />
-
**[[6b8e]], [[6b8t]], [[6b8x]], [[6b90]] – hPTPN1B catalytic domain<br />
+
**[[1a5y]], [[2hnp]], [[2hnq]], [[1oem]], [[1oeo]], [[1oes]], [[1oet]], [[1oeu]], [[1oev]], [[1sug]], [[2cm2]], [[2cm3]], [[3eu0]], [[3i80]], [[3a5j]], [[1bzc]], [[6b8e]], [[6b8t]], [[6b8x]], [[6b90]] - hPTP1B catalytic domain <br />
-
**[[6bai]] – hPTPN1B catalytic domain (mutant)<br />
+
**[[1gfy]], [[1i57]], [[1pa1]], [[2f6f]], [[3a5k]], [[3zv2]], [[3qkp]], [[3qkq]], [[6bai]] - hPTP1B catalytic domain (mutant) <br />
**[[2b49]] – hPTPN3 catalytic domain<br />
**[[2b49]] – hPTPN3 catalytic domain<br />
**[[4qun]] – hPTPN3 catalytic domain (mutant) <br />
**[[4qun]] – hPTPN3 catalytic domain (mutant) <br />
Line 49: Line 41:
**[[5glj]] - hPTPN13 PDZ1 domain <br />
**[[5glj]] - hPTPN13 PDZ1 domain <br />
**[[3lnx]] – hPTPN13 PDZ2 domain<br />
**[[3lnx]] – hPTPN13 PDZ2 domain<br />
 +
**[[3pdz]] - hPTPN13 PDZ2 domain – NMR<BR />
**[[2m0z]] - hPTPN13 PDZ2 domain (mutant) – NMR<br />
**[[2m0z]] - hPTPN13 PDZ2 domain (mutant) – NMR<br />
**[[2bzl]] – hPTPN14 catalytic domain<br />
**[[2bzl]] – hPTPN14 catalytic domain<br />
Line 58: Line 51:
**[[1r6h]], [[1v3a]], [[2mbc]] – hPTP PRL-3 – NMR<BR />
**[[1r6h]], [[1v3a]], [[2mbc]] – hPTP PRL-3 – NMR<BR />
**[[1rxd]] - hPTP IVA-1<br />
**[[1rxd]] - hPTP IVA-1<br />
 +
**[[1gm1]] - mPTP-BL PDZ2 domain – mouse – NMR<BR />
 +
**[[1ozi]] - mPTP-BL PDZ2 domain (mutant) – NMR<BR />
 +
**[[3rgo]] – mPTP-1<br />
 +
**[[2yz1]] – mPTP SHPS-1 catalytic domain<br />
**[[1zck]], [[1x24]] – rPTP 4A1 – rat<br />
**[[1zck]], [[1x24]] – rPTP 4A1 – rat<br />
**[[3i36]] – rPTP-η catalytic domain<br />
**[[3i36]] – rPTP-η catalytic domain<br />

Revision as of 20:42, 1 October 2018

Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, 3i7z

Drag the structure with the mouse to rotate

3D Structures of tyrosine phosphatase

Updated on 01-October-2018

References

  1. ↑ Paul S, Lombroso PJ. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci. 2003 Nov;60(11):2465-82. PMID:14625689 doi:http://dx.doi.org/10.1007/s00018-003-3123-7
  2. ↑ Caselli A, Paoli P, Santi A, Mugnaioni C, Toti A, Camici G, Cirri P. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme. Biochim Biophys Acta. 2016 Oct;1864(10):1339-55. doi:, 10.1016/j.bbapap.2016.07.001. Epub 2016 Jul 13. PMID:27421795 doi:http://dx.doi.org/10.1016/j.bbapap.2016.07.001
  3. ↑ Ostman A, Hellberg C, Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat Rev Cancer. 2006 Apr;6(4):307-20. PMID:16557282 doi:http://dx.doi.org/10.1038/nrc1837

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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